期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 55, 期 2, 页码 797-811出版社
IOS PRESS
DOI: 10.3233/JAD-160289
关键词
Aerosol; amyloid-beta; curcumin; nebulization
资金
- National Institutes of Health [R01CA16700]
- VICC Cancer Center Support grant
- National Center for Research Resources [UL1 RR024975-01]
- National Center for Advancing Translational Sciences [2 UL1 TR000445-06]
- Vanderbilt-Ingram Cancer Center Thoracic Program Initiative
We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer's disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals demonstrated remarkably improved overall cognitive function, no registered systemic or pulmonary toxicity associated with inhalable curcumin observed during the course of this work.
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