期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
卷 425, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2021.113656
关键词
Large Stokes shift; Viscosity; Polarity; Lipid droplets; Bio-probes
资金
- National Natural Science Foundation of China [21801145]
- Shandong Provincial Key R&D Pro-gram/Major Science and Technology Innovation Project of Shandong Province [2019JZZY020230]
- Shandong Provincial Natural Science Foundation [ZR2017BB012]
- Foundation of State Key Laboratory of Bio-based Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Sciences) [ZZ20200111]
Lipid droplets (LDs) play a crucial role in various cellular activities and are associated with human diseases. Two novel probes, LDP-1 and LDP-2, exhibit strong fluorescence in hydrophobic and high viscosity environments, with low biological toxicity and good selectivity for monitoring LDs distribution in living HeLa cells.
Lipid droplets (LDs) are involved in a variety of complex life activities in cells, which are closely related to human diseases including obesity, diabetes and cancer. LDs are generally considered as a kind of organelle with extremely low water content and high viscosity. Herein, two novel probes (E)-2-(3-(2-(7-(diethylamino)-2-oxo2H-chromen-3-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (LDP-1) and (E)-2-(3-(4-(diethylamino) styryl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (LDP-2) were synthesized, which exhibited large Stokes shifts of 4758 cm-1 and 3986 cm-1 respectively. The two probes emitted strongly in hydrophobic and high viscosity environments. Moreover, bio-probes LDP-1 and LDP-2 exhibited low biological toxicity, and good selectivity. The two probes were also fit for selectively monitoring LDs distribution in living HeLa cells.
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