期刊
JOURNAL OF PEDIATRICS
卷 248, 期 -, 页码 21-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2022.05.039
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类别
资金
- National Institute on Drug Abuse [R01 DA08524, R01 DA016373]
- US Department of Education's Cognition and Student Learning Program [R30 5H020035]
- Blue Cross Blue Shield of Michigan Foundation [2206.II]
- National Institute of Environmental Health Sciences [P30 ES020957]
Community violence exposure is a significant risk factor for hypertension in young Black American adults. The higher exposure to community violence among Black American children compared to other races may contribute to racial disparities in hypertension burden among adults.
Objective To test the impact of childhood adversity, including community violence exposure, on hypertension risk in Black American young adults to understand what risk factors (eg, prenatal factors, later exposures) and ages of adversity exposure increased hypertension risk. Study design The study included 396 Black American participants with data from prenatal, birth, and age 7-, 14-, and 19-year visits. At age 19 years, individuals with blood pressure (BP) measures >120 mmHg systolic and/or >80 mmHg diastolic were classified as having high blood pressure (HBP), and those with BP <120/80 mmHg were classified as normal. Associations between prenatal and birth risk factors; childhood adversity at age 7, 14, and 19 years; age 19 body mass index (BMI); and both systolic and diastolic BP at age 19 were tested using logistic regression models. Results Age 19 BMI was positively associated with systolic and diastolic HBP status at age 19. Controlling for all covariates, community violence exposure at age 7 and 19 years was associated with 2.2-fold (95% CI, 1.242-3.859) and 2.0-fold (95% CI, 1.052-3.664) greater odds of systolic HBP, respectively, at age 19 years. Prenatal risk, birth risk, and other dimensions of childhood adversity were not associated with HBP in this cohort. Conclusion Childhood community violence exposure is a significant risk factor for HBP in young adults. As Black American children typically experience more community violence exposure than other American children, our results suggest that racial disparities in childhood community violence exposure may contribute to racial disparities in adult hypertension burden. (J Pediatr 2022;248:21-9).
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