Comparative assessment of heterogeneous and homogeneous Suzuki-Miyaura catalytic reactions using bio-Profiles and bio-Factors

Transition metals are essential for most catalytic systems in fine organic synthesis. The usage of transition metals has traditionally raised concerns about their toxicity and potential environmental pollution problems. In this context, the issue of preference for supported catalysts, which can be easily removed from the reaction mixture, over metal complex catalysts is of significant relevance. In this work, we used bio-Profiles and bio-Factors of chemical reactions to assess the impact of catalyst type on the toxicity of a reaction system in the practically important Suzuki-Miyaura reaction. The supported catalysts had noticeably lower cytotoxicity than soluble metal complex catalysts. However, the combined effect of supported catalysts on the environment can depend on their preparation procedure and may have a noticeable neglected biological impact. Both types of catalysts made no significant contribution to the overall toxicity of the systems studied, while common and typically ignored byproducts demonstrated significantly higher overall biological influence. In the present study, we describe how to use bio-Profiles in order to visualize and analyze the biological properties of different types of catalytic reactions.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

Transition metals are crucial in fine organic synthesis, but their toxicity and environmental pollution have raised concerns. The comparison between supported catalysts and soluble metal complex catalysts revealed that supported catalysts have lower cytotoxicity, but their overall impact on the environment can vary depending on the preparation procedure and may have neglected biological effects. Both types of catalysts did not significantly contribute to the overall toxicity of the systems, while commonly ignored byproducts showed higher overall biological influence.