4.7 Article

Catalytic Diastereo- and Enantioselective Synthesis of TertiaryTrifluoromethyl Carbinols through a Vinylogous Aldol Reaction ofAlkylidenepyrazolones with Trifluoromethyl Ketones

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Organic

Recent Advances in Catalytic Enantioselective Synthesis of Pyrazolones with a Tetrasubstituted Stereogenic Center at the 4-Position

Laura Carceller-Ferrer et al.

Summary: Pyrazolone is an important nitrogen heterocycle found in pharmaceutical drugs and molecules with biological activity. Recent advancements have led to successful catalytic methodologies for asymmetric synthesis of chiral pyrazolones, particularly those with a tetrasubstituted stereocenter at C-4.

SYNTHESIS-STUTTGART (2021)

Article Chemistry, Organic

Catalytic Diastereo- and Enantioselective Vinylogous Mannich Reaction of Alkylidenepyrazolones to Isatin-Derived Ketimines

Laura Carceller-Ferrer et al.

Summary: A valuable organocatalytic vinylogous Mannich reaction has been established between alkylidenepyrazolones and isatin-derived ketimines. The reaction was catalyzed by a squaramide organocatalyst, resulting in a range of aminooxindole-pyrazolone adducts with excellent outcomes, including high yields and selectivities.

ORGANIC LETTERS (2021)

Review Chemistry, Medicinal

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Zefeng Zhao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Contribution of Organofluorine Compounds to Pharmaceuticals

Munenori Inoue et al.

ACS OMEGA (2020)

Article Chemistry, Organic

Organocatalytic Asymmetric Formal [3+3]-Cycloaddition to Access 2,3-Diazaspiro[4.5]deca-3,6-dien-1-ones

A. Vamshi Krishna et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2020)

Article Chemistry, Organic

Organocatalytic enantioselective aminoalkylation of pyrazol-3-ones with aldimines generated in situ from α-amido sulfones

Laura Carceller-Ferrer et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2019)

Review Chemistry, Organic

Catalytic Asymmetric Synthesis of alpha-Trifluoromethylated Carbinols: A Case Study of Tertiary Propargylic Alcohols

Hidetoshi Noda et al.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2018)

Article Chemistry, Applied

Organocatalytic Enantioselective Strecker Reaction with Seven-Membered Cyclic Imines

Carles Lluna-Galan et al.

ADVANCED SYNTHESIS & CATALYSIS (2018)

Review Chemistry, Multidisciplinary

Pyrazolone: a powerful synthon for asymmetric diverse derivatizations

Siyuan Liu et al.

CHEMICAL COMMUNICATIONS (2018)

Article Chemistry, Applied

Asymmetric Construction of Spiropyrazolone Skeletons via Amine-Catalyzed [3+3] Annulation

Hai-Jun Leng et al.

ADVANCED SYNTHESIS & CATALYSIS (2018)

Article Chemistry, Multidisciplinary

Enantioselective Synthesis of Spirocyclohexadienones by NHC-Catalyzed Formal [3+3] Annulation Reaction of Enals

Santhivardhana Reddy Yetra et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Chemistry, Multidisciplinary

Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

Carlos Vila et al.

CHEMISTRY-AN ASIAN JOURNAL (2016)

Article Chemistry, Multidisciplinary

Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives

Pankaj Chauhan et al.

CHEMICAL COMMUNICATIONS (2015)

Article Chemistry, Multidisciplinary

Functionalization of Benzylic C(sp3)-H Bonds of Heteroaryl Aldehydes through N-Heterocyclic Carbene Organocatalysis

Xingkuan Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Article Chemistry, Multidisciplinary

Highly Enantioselective Organocatalytic Trifluoromethyl Carbinol Synthesis-A Caveat on Reaction Times and Product Isolation

Nongnaphat Duangdee et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Review Chemistry, Organic

Organocatalytic Asymmetric Vinylogous Aldol Reactions

Vishnumaya Bisai

SYNTHESIS-STUTTGART (2012)

Review Chemistry, Multidisciplinary

The Vinylogous Aldol and Related Addition Reactions: Ten Years of Progress

Giovanni Casiraghi et al.

CHEMICAL REVIEWS (2011)

Review Chemistry, Multidisciplinary

Squaramides: Bridging from Molecular Recognition to Bifunctional Organocatalysis

Jose Aleman et al.

CHEMISTRY-A EUROPEAN JOURNAL (2011)

Review Chemistry, Multidisciplinary

The Organocatalytic Vinylogous Aldol Reaction: Recent Advances

Sunil V. Pansare et al.

CHEMISTRY-A EUROPEAN JOURNAL (2011)

Review Chemistry, Multidisciplinary

Fluorine in medicinal chemistry

Sophie Purser et al.

CHEMICAL SOCIETY REVIEWS (2008)

Review Chemistry, Multidisciplinary

Small-molecule H-bond donors in asymmetric catalysis

Abigail G. Doyle et al.

CHEMICAL REVIEWS (2007)

Review Chemistry, Multidisciplinary

The vinylogous aldol reaction: A valuable, yet understated carbon-carbon bond-forming maneuver

G Casiraghi et al.

CHEMICAL REVIEWS (2000)