期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 87, 期 8, 页码 5065-5075出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02915
关键词
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资金
- graduate research and innovation foundation of Chongqing, China [CYS17018]
- National Natural Science Foundation of China [21372265, 21350110501, 22161045]
- Natural Science Foundation Project of CQ CSTC [cstc2018jcyjAX0155]
In this study, a series of polycyclic compounds with altenuene backbone were successfully synthesized through PhI(OAc)2-oxidized dearomatization and diesterification. The Umpolung diesterification reaction occurred under mild conditions without the need for an additional nucleophilic reagent. This provides a concise method for the synthesis of diverse natural altenuene analogues.
Through PhI(OAc)2-oxidized dearomatization and diesterification of 3 '-hydroxy-[1,1 '-biphenyl]-2-carboxylic acids, aseries of polycyclic compounds possessing an altenuene backbone were obtained in moderate to good yields. The Umpolungdiesterification reaction was completed under mild reaction conditions without an additional nucleophilic reagent. This work offers aconcise method for the synthesis of diverse natural altenuene analogues. The mechanism was proposed, and the [1,5]-H shift wasstudied in isomerization from the ketone-form structure to a phenol employing computational studies.
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