期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 87, 期 6, 页码 4112-4123出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02909
关键词
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资金
- National Nature Science Foundation of China [21907114, 21662049]
- Science and Technology Department of Guizhou Province [QKHJC-2016-1421]
- Science and Technology Department of Zunyi [ZSKRPT-2020-5]
- Program for Outstanding Youth of Zunyi Medical University [17zy-005]
This article describes an inexpensive copper-catalyzed sequential reaction process for synthesizing structurally diverse spiro-dihydropmolo[1,2-a]quinoxaline derivatives. The significance of this method is highlighted by its ability to convert synthetic compounds into potentially bioactive molecules.
An inexpensive copper-catalyzed sequential reaction process, proceeding via a nucleophilic attack of amine to Cu-carbene generated in situ from heterocyclic N-tosylhydrazone precursors followed by a 1,2-H shift/oxidative cyclization cascade of N-ylides, has been described, smoothly generating the corresponding structurally various spiro-dihydropmolo[1,2-a]quinoxaline derivatives. Furthermore, the significance of this protocol can be also highlighted by its diverse conversions of the synthetic compounds to the potentially bioactive molecules such as the 2-substituted pyrrolo[1,2-a]quinoxalins.
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