Free Radical Cascade Carbochloromethylations of Activated Alkenes

Free radical carbochloromethylations of ortho-cyanoarylacrylamides and N-(arylsulfonyl)acrylamides have been developed by employing simple alkyl chlorides as the chloromethyl source. The transformations are characterized by wide functional group compatibility and utilizing readily available reagents, thus providing efficient methods for constructing polychloromethyl-substituted quinoline-2,4-diones and alpha-aryl-beta-polychloromethylated amides.

Automated summary

Free radical carbochloromethylation reactions of ortho-cyanoarylacrylamides and N-(arylsulfonyl)acrylamides have been developed using simple alkyl chlorides as the chloromethyl source. These transformations exhibit wide functional group compatibility and provide efficient methods for constructing polychloromethyl-substituted quinoline-2,4-diones and alpha-aryl-beta-polychloromethylated amides.