Synthesis of 3-Trifluoromethyl-1,2,4-triazolines and 1,2,4-Triazolesvia Tandem Addition/Cyclization of Trifluoromethyl N-Acylhydrazones with Cyanamide

A tandem addition/cyclization reaction between trifluoromethylN-acylhydrazones and cyanamide is described,which provides a novel and efficient process for the synthesis ofpolysubstituted 3-trifluoromethyl-1,2,4-triazolines and their deriv-atives. The method has the advantages of mild reaction conditions,a broad substrate scope, good product yields, and atom economy

Automated summary

A new and efficient method for the synthesis of polysubstituted 3-trifluoromethyl-1,2,4-triazolines and their derivatives is described, involving a tandem addition/cyclization reaction between trifluoromethylN-acylhydrazones and cyanamide. The method offers mild reaction conditions, a broad substrate scope, good product yields, and atom economy.