期刊
JOURNAL OF NEUROLOGY
卷 269, 期 9, 页码 5127-5135出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-022-11169-w
关键词
Multiple sclerosis; Burden of illness; Cost of illness; Healthcare costs; Payer; Italy
资金
- Novartis Farma S.p.A
This study estimates the burden and cost of illness of multiple sclerosis (MS) in Italy in 2019 from a societal perspective. The results show a significant impact of the disease on patients' daily activities and work, increasing with disability. Fatigue is identified as a major burden. The overall cost of the disease in Italy is estimated at 4.8 billion euros.
Background Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease negatively impacting patients' physical, psychological and social well-being with a significant economic burden. Objectives The study estimates MS burden and cost of illness in Italy from a societal perspective in 2019. Methods Information on the impact of the disease on daily activities, symptoms, employment, resource utilization and the role of caregivers was collected through questionnaires completed by 944 patients and caregivers. Results were stratified according to both disease severity and payer. Mean costs and overall costs were extrapolated from the sample to the Italian MS population considering published distribution of severity. Results The study showed a great impact of the disease on daily and work activities increasing with the disability. The overwhelming burden of fatigue emerged. Mean annual costs were estimated at euro39,307/patient (euro29,676, euro43,464 and euro53,454 in mild, moderate and severe cases, respectively). Direct healthcare costs were the major component (euro21,069), followed by indirect costs (euro15,004). The overall cost of the disease in Italy was euro4.8 billion. The National Healthcare System (NHS) sustained most of the costs (80%), most notably direct healthcare costs, while patients paid almost all non-healthcare expenses. Conclusions This study confirmed that MS carries a substantial burden to patients and society, highlighting the need for awareness of this disease.
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