☆ 4.7 Article

Evaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model

JOURNAL OF NEUROINFLAMMATION (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Ophthalmology

Inflammation in Glaucoma: From the back to the front of the eye, and beyond

Christophe Baudouin et al.

Summary: The pathophysiology of glaucoma is complex and multifactorial, involving elevated intraocular pressure and impaired retinal blood flow as primary factors. Oxidative stress, cell senescence, mitochondrial dysfunction, excitotoxicity, and neuroinflammation play crucial roles in glaucoma progression. Inflammatory processes in various ocular structures from the posterior to the anterior segment are present in glaucoma, supporting the hypothesis of dysregulation towards a pro-inflammatory phenotype. Possible anti-inflammatory therapeutic approaches for glaucoma are also discussed.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

添加到收藏夹

Article Ophthalmology

Retinal function after intravitreal injection of autologous bone marrow-derived mesenchymal stromal cells in advanced glaucoma

Carolina Assis P. Vilela et al.

Summary: The study reported on the use of bone marrow-derived mesenchymal stem cells (MSCs) in treating advanced glaucoma, with no improvement seen in visual acuity or visual field post-treatment. Although one patient experienced retinal detachment and proliferative vitreoretinopathy after 15 days, the other patient showed stable ERG responses throughout the study period. Further research involving modified MSCs is needed to address the lack of visual function improvement observed in the study.

DOCUMENTA OPHTHALMOLOGICA (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Therapeutic Properties of Mesenchymal Stromal/Stem Cells: The Need of Cell Priming for Cell-Free Therapies in Regenerative Medicine

Vitale Miceli et al.

Summary: MSCs are multipotent adult stem cells that support tissue regeneration, and their therapeutic effects are derived from the secretion of bioactive molecules. However, variables in clinical trials have led to inconsistent outcomes. Therefore, exploring the paracrine action of MSCs to enhance therapeutic benefits by modulating the composition of secretome is a promising approach for tissue regeneration.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Future of Stem Cells and Their Derivates in the Treatment of Glaucoma. A Critical Point of View

Simona Delia Nicoara et al.

Summary: The clinical translation of preclinical studies using stem cells in the treatment of glaucoma, specifically optic nerve regeneration, faces challenges due to complex pathophysiological mechanisms and varying treatment outcomes. Lessons learned include the importance of stem cell type, administration route, patient selection, additional therapies, and methods to avoid immune response. Exosomes and miRNA show promise for more targeted approaches with minimal side effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Intravitreal autologous mesenchymal stem cell transplantation: a non-randomized phase I clinical trial in patients with retinitis pigmentosa

Aekkachai Tuekprakhon et al.

Summary: Intravitreal injection of BM-MSCs was found to be safe and potentially effective in treating advanced RP. The study observed mild and transient adverse events in the short-term, with improvements in BCVA but no remarkable progression in VF and CST. Long-term follow-up suggested the need for further assessment with larger sample sizes and less advanced cases.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Review Cell Biology

Mesenchymal Stem Cell-Based Therapy for Retinal Degenerative Diseases: Experimental Models and Clinical Trials

Vladimir Holan et al.

Summary: Cell therapy using mesenchymal stem cells (MSCs) offers a potential treatment option for retinal degenerative diseases by utilizing the cells' immunoregulatory and anti-inflammatory properties to support retinal cell survival and growth. MSCs also have the potential to protect retinal cells and contribute to the regeneration of the diseased retina.

CELLS (2021)

添加到收藏夹

Review Clinical Neurology

Glial Cells in Glaucoma: Friends, Foes, and Potential Therapeutic Targets

Mariana Y. Garcia-Bermudez et al.

Summary: Glaucoma is the second leading cause of blindness worldwide, affecting around 80 million people by 2020. Despite lowering intraocular pressure being the only proven treatment to slow disease progression, a significant number of patients still go blind. Therefore, the search for alternative treatment strategies is crucial.

FRONTIERS IN NEUROLOGY (2021)

添加到收藏夹

Article Cell Biology

Uptake and Distribution of Administered Bone Marrow Mesenchymal Stem Cell Extracellular Vesicles in Retina

Biji Mathew et al.

Summary: Mesenchymal Stem Cell Exosomes/Extracellular Vesicles (MSC EVs) are a promising alternative for treating retinal diseases, promoting immunomodulation, repair, and regeneration. Studies in rats and in vitro experiments have shown that intravitreally administered EVs are effective for treating diseases affecting the inner retina.

CELLS (2021)

添加到收藏夹

Article Immunology

Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice

Kazadi Nadine Mutoji et al.

Summary: The glial scar surrounding penetrating brain injuries plays a crucial role in limiting inflammatory response and protecting uninjured tissue. Recent research suggests that TSG-6, an anti-inflammatory molecule, within the glial scar contributes to this protective function. The absence of TSG-6 results in a more severe inflammatory response and increased astrogliosis beyond the injury site in mice, indicating the anti-inflammatory role of TSG-6 within the glial scar.

BMC IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

1α,25-dihydroxyvitamin D3 protects retinal ganglion cells in glaucomatous mice

Francesca Lazzara et al.

Summary: The study found that treatment with 1,25(OH)(2)D-3 can improve retinal function in age-related glaucomatous mice, reduce retinal ganglion cell death, and decrease the expression of inflammatory cytokines. This may help alleviate retinal damage in glaucoma patients and merits further clinical evaluation for the treatment of optic neuropathies.

JOURNAL OF NEUROINFLAMMATION (2021)

添加到收藏夹

Article Immunology

Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response

Yonghui Hou et al.

Summary: In this study, TUDCA was shown to attenuate axon degeneration induced by oxidative stress in vitro and protect primary cortical neurons. In vivo, TUDCA treatment reduced tissue injury, oxidative stress, inflammation, and apoptosis, while promoting axon regeneration and remyelination in SCI mice. The functional recovery test also indicated that TUDCA treatment significantly improved limb function recovery after SCI.

JOURNAL OF NEUROINFLAMMATION (2021)

添加到收藏夹

Review Cell & Tissue Engineering

Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases

Giuliana Mannino et al.

Summary: Stem cell-based therapies offer promising outcomes in the treatment of eye diseases, particularly through the paracrine activity of MSCs. Clinical trials have shown positive results, suggesting that safer and more effective protocols may be developed in the future for broader clinical applications.

WORLD JOURNAL OF STEM CELLS (2021)

添加到收藏夹

Review Cell Biology

Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation?

Stephane Melik Parsadaniantz et al.

CELLS (2020)

添加到收藏夹

Review Cell Biology

Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials

Yiqi Wang et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Myh11+microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis

H. Clifton Ray et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Differential Distribution of RBPMS in Pig, Rat, and Human Retina after Damage

Xandra Pereiro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Ophthalmology

Proteomics reveals a set of highly enriched proteins in epiretinal membrane compared with inner limiting membrane

Christos Christakopoulos et al.

EXPERIMENTAL EYE RESEARCH (2019)

添加到收藏夹

Review Ophthalmology

Retinal explant culture: A platform to investigate human neuro-retina

Aparna Murali et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2019)

添加到收藏夹

Article Neurosciences

Mesenchymal stem cells enhance microglia M2 polarization and attenuate neuroinflammation through TSG-6

Yi Liu et al.

BRAIN RESEARCH (2019)

添加到收藏夹

Article Ophthalmology

Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology

Virpi Alarautalahti et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2019)

添加到收藏夹

Review Cell Biology

Neuroinflammation as a target for glaucoma therapy

Annagrazia Adornetto et al.

NEURAL REGENERATION RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Concentrated Conditioned Media from Adipose Tissue Derived Mesenchymal Stem Cells Mitigates Visual Deficits and Retinal Inflammation Following Mild Traumatic Brain Injury

Kumar Abhiram Jha et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Review Endocrinology & Metabolism

The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke

Catriona J. Cunningham et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2018)

添加到收藏夹

Review Anatomy & Morphology

Current Advancements in the Development and Characterization of Full-Thickness Adult Neuroretina Organotypic Culture Systems

Christina L. Rettinger et al.

CELLS TISSUES ORGANS (2018)

添加到收藏夹

Review Ophthalmology

Stem Cell Treatment in Retinal Diseases: Recent Developments

Ayse Oner

TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Vision Loss after Intravitreal Injection of Autologous Stem Cells for AMD

Ajay E. Kuriyan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

添加到收藏夹

Review Cell & Tissue Engineering

Effect of the Microenvironment on Mesenchymal Stem Cell Paracrine Signaling: Opportunities to Engineer the Therapeutic Effect

Gina D. Kusuma et al.

STEM CELLS AND DEVELOPMENT (2017)

添加到收藏夹

Article Anatomy & Morphology

Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration

Tian Zhou et al.

FRONTIERS IN NEUROANATOMY (2017)

添加到收藏夹

Article Cell & Tissue Engineering

Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms

Ben Mead et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

添加到收藏夹

Review Immunology

The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?

F. Carty et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)

添加到收藏夹

Review Neurosciences

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Yu Tang et al.

MOLECULAR NEUROBIOLOGY (2016)

添加到收藏夹

Review Cell & Tissue Engineering

The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration

Vijay Bhaskar Reddy Konala et al.

CYTOTHERAPY (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Retinal ganglion cell death in glaucoma: Exploring the role of neuroinflammation

Rossella Russo et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

添加到收藏夹

Article Ophthalmology

A mouse retinal explant model for use in studying neuroprotection in glaucoma

Ushasree Pattamatta et al.

EXPERIMENTAL EYE RESEARCH (2016)

添加到收藏夹

Article Cell & Tissue Engineering

Distinct Immunoregulatory Mechanisms in Mesenchymal Stem Cells: Role of the Cytokine Environment

Vladimir Holan et al.

STEM CELL REVIEWS AND REPORTS (2016)

添加到收藏夹

Article Cell & Tissue Engineering

Distinct Immunoregulatory Mechanisms in Mesenchymal Stem Cells: Role of the Cytokine Environment

Vladimir Holan et al.

STEM CELL REVIEWS AND REPORTS (2016)

添加到收藏夹

Article Neurosciences

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro

João Martins et al.

ASN Neuro (2015)

添加到收藏夹

Article Cell & Tissue Engineering

Neuroprotective effects of intravitreally transplanted adipose tissue and bone marrow-derived mesenchymal stem cells in an experimental ocular hypertension model

Esra Emre et al.

CYTOTHERAPY (2015)

添加到收藏夹

Article Cell & Tissue Engineering

Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation

Alessia Tassoni et al.

STEM CELLS (2015)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

US stem cell clinics, patient safety, and the FDA

Leigh Turner

TRENDS IN MOLECULAR MEDICINE (2015)

添加到收藏夹

Article Cell & Tissue Engineering

Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma

Christophe Roubeix et al.

STEM CELL RESEARCH & THERAPY (2015)

添加到收藏夹

Article Clinical Neurology

Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome

Thomas V. Johnson et al.

BRAIN (2014)

添加到收藏夹

Review Neurosciences

The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina

Allen R. Rodriguez et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2014)

添加到收藏夹

Review Immunology

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

Jonathan D. Cherry et al.

JOURNAL OF NEUROINFLAMMATION (2014)

添加到收藏夹

Review Medicine, Research & Experimental

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

Marialaura Madrigal et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

添加到收藏夹

Editorial Material Chemistry, Multidisciplinary

The good and bad of microglia/macrophages: new hope in stroke therapeutics

Ya-chi Huang et al.

ACTA PHARMACOLOGICA SINICA (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

Fabio G. Teixeira et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

添加到收藏夹

Article Neurosciences

The mechanism of axonal degeneration after perikaryal excitotoxic injury to the retina

Natalie D. Bull et al.

EXPERIMENTAL NEUROLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

Mark M. Magharious et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2011)

添加到收藏夹

Article Ophthalmology

Use of an Adult Rat Retinal Explant Model for Screening of Potential Retinal Ganglion Cell Neuroprotective Therapies

Natalie D. Bull et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

添加到收藏夹

Article Ophthalmology

Neuroprotective Effects of Intravitreal Mesenchymal Stem Cell Transplantation in Experimental Glaucoma

Thomas V. Johnson et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)

添加到收藏夹

Article Ophthalmology

Development and characterization of an adult retinal explant organotypic tissue culture system as an in vitro intraocular stem cell transplantation model

Thomas V. Johnson et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

添加到收藏夹

Review Immunology

The chemokine system in diverse forms of macrophage activation and polarization

A Mantovani et al.

TRENDS IN IMMUNOLOGY (2004)

添加到收藏夹

Article Hematology

Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli

M Di Nicola et al.

BLOOD (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.