A tumefactive anti-MOG antibody associated disorder heralding central nervous system B-cell lymphoma: Case report on diagnostic challenge

We present the case of a 52-year-old woman with right hemiparesis due to a mass lesion in the left parietal white matter and corpus callosum. The lesion was hyperintense on diffusion weighted image and homogenously enhanced with gadolinium on magnetic resonance imaging, and was radiologically indistinguishable with lymphoma. Following progressive aggravation of symptoms, craniotomy for biopsy of the lesion was performed, and it was revealed that the patient had anti-myelin oligodendrocyte glycoprotein-associated disease by histopathological and serological diagnosis. Initial treatment with steroid dramatically improved the symptoms, but they exacerbated again. Then, through cerebrospinal fluid examination, it was revealed that the patient had B cell lymphoma.

Automated summary

This case report describes a 52-year-old woman with right hemiparesis caused by a mass lesion in the left parietal white matter and corpus callosum. The patient was initially diagnosed with anti-myelin oligodendrocyte glycoprotein-associated disease and showed improvement with steroid treatment, but was later diagnosed with B cell lymphoma through cerebrospinal fluid examination.