Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis

Methods: Cerebrospinal fluid (CSF) and plasma levels of 38 biomarkers from 20 neurosarcoidosis (NS) patients were compared to healthy controls (HC).Results: In CSF, 25 biomarkers were significantly elevated compared to HC: IFN gamma, TNF alpha, TNF beta, IL-2, IL-6, IL-10, IL-12B, IL-15, IL-16, CCL2, CCL3, CCL4, CCL11, CCL13, CCL17, CCL22, CCL26, CXCL8, CXCL10, TNFR2, VEGF-A, PIGF, SAA, VCAM1, and ICAM1. In plasma, 12 biomarkers were significantly elevated compared to HC: IFN gamma, TNF alpha, CCL2, CCL3, CCL4, CCL17, CXCL10, VEGFR1, PIGF, SAA, VCAM1, and ICAM1.Conclusion: NS patients have profoundly elevated cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in CSF and plasma.

Automated summary

Neurosarcoidosis patients have significantly elevated levels of cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in cerebrospinal fluid (CSF) and plasma.