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Focused ultrasound for the treatment of glioblastoma

JOURNAL OF NEURO-ONCOLOGY (2022)

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Article Clinical Neurology

Safety and feasibility of multiple blood-brain barrier disruptions for the treatment of glioblastoma in patients undergoing standard adjuvant chemotherapy

So Hee Park et al.

Summary: This study evaluated the safety and feasibility of repeated disruption of the blood-brain barrier with MR-guided focused ultrasound in patients with glioblastoma during standard chemotherapy, showing accurate and safe performance without clinical adverse effects.

JOURNAL OF NEUROSURGERY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Synthetic generation of DSC-MRI-derived relative CBV maps from DCE MRI of brain tumors

Jeremiah W. Sanders et al.

Summary: Perfusion MRI using gadolinium-based contrast agents is important for brain tumor diagnosis and treatment response evaluation. Synthesizing rCBV maps from DCE MRI enables robust brain tumor perfusion imaging with a single gadolinium-based contrast agent administration.

MAGNETIC RESONANCE IN MEDICINE (2021)

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Review Clinical Neurology

Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Ying Meng et al.

Summary: Focused ultrasound (FUS) is a disruptive medical technology that can precisely intervene in key circuits of brain disorders, with various forms of actions such as blood-brain barrier opening and neuromodulation. In recent years, there has been a significant expansion of FUS applications in humans, leading to increased academic and public interest in the technology.

NATURE REVIEWS NEUROLOGY (2021)

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Article Chemistry, Multidisciplinary

ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma

Natasha D. Sheybani et al.

Summary: Phagocytic immunotherapies, such as CD47 blockade, have shown promise in treating glioblastoma (GB). Overcoming the challenges posed by the blood brain/tumor barriers (BBB/BTB) for mCD47 delivery through focused ultrasound (FUS) is crucial. Timing of antibody injection relative to FUS BBB/BTB disruption is essential for optimal mCD47 access to gliomas. Repeat sessions of FUS can significantly constrain tumor outgrowth and extend survival in glioma-bearing mice, making mCD47 delivery with FUS a promising therapeutic strategy for GB therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Oncology

MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors

Ying Meng et al.

Summary: This study demonstrates that MRgFUS has the potential to enrich circulating brain-derived biomarkers, showing promising applications for liquid biopsy in the brain.

NEURO-ONCOLOGY (2021)

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Review Medicine, General & Internal

Sonodynamic Therapy for the Treatment of Intracranial Gliomas

Antonio D'Ammando et al.

Summary: SDT shows promise as a treatment for malignant gliomas, combining low-intensity ultrasound waves with sensitizing compounds to enhance immunogenicity, increase apoptotic rates, and reduce angiogenetic potential in tumor cells. Preclinical studies have confirmed its anti-tumoral properties and first clinical trials are set to begin recruiting patients. Further investigations are needed to explore the clinical applications of SDT for intracranial gliomas.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Oncology

Role of Dynamic Susceptibility Contrast Perfusion MRI in Glioma Progression Evaluation

Guanmin Quan et al.

Summary: The study suggests that combining DSC-MRI with conventional MRI can improve the diagnostic performance for identifying true progression and pseudoprogression in glioma patients, achieving a high sensitivity and specificity. This approach may promptly distinguish these conditions without the need for long-term follow-up.

JOURNAL OF ONCOLOGY (2021)

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Article Pharmacology & Pharmacy

Focused Ultrasound-Enhanced Delivery of Intranasally Administered Anti-Programmed Cell Death-Ligand 1 Antibody to an Intracranial Murine Glioma Model

Dezhuang Ye et al.

Summary: The study demonstrated that FUSIN technique could effectively enhance the delivery of anti-programmed cell death-ligand 1 antibody (aPD-L1) to the brain, providing a potential approach to improve the therapeutic efficacy of immune checkpoint inhibitors for gliomas.

PHARMACEUTICS (2021)

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Article Clinical Neurology

DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: A Biopsy Study

Vera C. Keil et al.

Summary: The study found that DCE-MRI kinetic parameters are correlated with microvascular parameters in gliomas and can be used to predict neovascularization. Differences in K-trans and v(e) values were observed in the infiltration zones of patients in different prognostic groups, and significant differences were found in vascular parameters between vital tumor tissue and infiltration zones.

CLINICAL NEURORADIOLOGY (2021)

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Article Multidisciplinary Sciences

Focused ultrasound mediated blood-brain barrier opening is safe and feasible in a murine pontine glioma model

Zachary K. Englander et al.

Summary: The study demonstrated that FUS is a safe and feasible technique for opening the BBB and delivering drugs to the brainstem efficiently without causing significant adverse reactions. Furthermore, FUS can significantly increase drug concentration within the tumor, providing a new direction for the treatment of pontine glioma.

SCIENTIFIC REPORTS (2021)

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Article Engineering, Biomedical

Contrast-Free Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening Using Diffusion Tensor Imaging

Maria Eleni Karakatsani et al.

Summary: The study investigated the use of diffusion tensor imaging for detecting focused ultrasound-induced blood-brain barrier opening, showing an increase in fractional anisotropy and diffusion anisotropy enhancement post-BBB opening. The experiment confirmed the feasibility of the technique and suggested its potential as a contrast-free MRI modality for evaluating BBB integrity in brain-related pathologies.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2021)

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Article Multidisciplinary Sciences

Localized blood-brain barrier opening in infiltrating gliomas with MRI-guided acoustic emissions-controlled focused ultrasound

Pavlos Anastasiadis et al.

Summary: This study evaluates the safety and utility of microbubble-enhanced focused ultrasound for spatially targeted blood-brain barrier opening in patients with infiltrating gliomas.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Oncology

Immunological Effects of Histotripsy for Cancer Therapy

Alissa Hendricks-Wenger et al.

Summary: Immunomodulating therapies have become a key approach in the treatment of cancer, addressing not only primary tumors but also circulating tumor cells and distant metastases. Focal ablation therapies, such as histotripsy, have shown promise in debulking tumors and stimulating an immune response. Studies also suggest that histotripsy may have reproducible immune effects across different tumor types.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Radiosensitization of high-grade gliomas through induced hyperthermia: Review of clinical experience and the potential role of MR-guided focused ultrasound

Craig S. Schneider et al.

RADIOTHERAPY AND ONCOLOGY (2020)

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Review Clinical Neurology

Focused Ultrasound Strategies for Brain Tumor Therapy

Adomas Bunevicius et al.

OPERATIVE NEUROSURGERY (2020)

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Article Multidisciplinary Sciences

Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model

Christopher Pham Pacia et al.

SCIENTIFIC REPORTS (2020)

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Review Oncology

Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways

Brita Singers Sorensen et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

Fluorescein-mediated sonodynamic therapy in a rat glioma model

Francesco Prada et al.

JOURNAL OF NEURO-ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Consistent opening of the blood brain barrier using focused ultrasound with constant intravenous infusion of microbubble agent

Norman A. Lapin et al.

SCIENTIFIC REPORTS (2020)

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Article Oncology

One-Year Outcome of Multiple Blood-Brain Barrier Disruptions With Temozolomide for the Treatment of Glioblastoma

So Hee Park et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Pharmacology & Pharmacy

Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound

Ambre Dauba et al.

PHARMACEUTICS (2020)

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Article Medicine, Research & Experimental

Focused Ultrasound Hyperthermia Augments Release of Glioma-derived Extracellular Vesicles with Differential Immunomodulatory Capacity

Natasha D. Sheybani et al.

THERANOSTICS (2020)

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Article Oncology

Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma

Ahmed Idbaih et al.

CLINICAL CANCER RESEARCH (2019)

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Article Acoustics

SONODYNAMIC THERAPY FOR MALIGNANT GLIOMA USING 220-KHZ TRANSCRANIAL MAGNETIC RESONANCE IMAGING-GUIDED FOCUSED ULTRASOUND AND 5-AMINOLEVULINIC ACID

Michiharu Yoshida et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2019)

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Review Acoustics

ULTRASOUND HYPERTHERMIA TECHNOLOGY FOR RADIOSENSITIZATION

Lifei Zhu et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2019)

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Article Multidisciplinary Sciences

MR-guided Focused Ultrasound Facilitates Sonodynamic Therapy with 5-Aminolevulinic Acid in a Rat Glioma Model

Sheng-Kai Wu et al.

SCIENTIFIC REPORTS (2019)

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Article Clinical Neurology

In vivo histotripsy brain treatment

Jonathan R. Sukovich et al.

JOURNAL OF NEUROSURGERY (2019)

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Article Multidisciplinary Sciences

Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study

Todd Mainprize et al.

SCIENTIFIC REPORTS (2019)

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Review Medicine, Research & Experimental

Perspectives on Recent Progress in Focused Ultrasound Immunotherapy

Natasha D. Sheybani et al.

THERANOSTICS (2019)

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Article Oncology

Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma

Benjamin M. Ellingson et al.

NEURO-ONCOLOGY (2018)

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Article Multidisciplinary Sciences

Focused Ultrasound-enabled Brain Tumor Liquid Biopsy

Lifei Zhu et al.

SCIENTIFIC REPORTS (2018)

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Article Medicine, Research & Experimental

Tumour Vascular Shutdown and Cell Death Following Ultrasound-Microbubble Enhanced Radiation Therapy

Ahmed El Kaffas et al.

THERANOSTICS (2018)

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Review Oncology

Thermal and mechanical high-intensity focused ultrasound: perspectives on tumor ablation, immune effects and combination strategies

Renske J. E. van den Bijgaart et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)

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Review Clinical Neurology

Modified Criteria for Radiographic Response Assessment in Glioblastoma Clinical Trials

Benjamin M. Ellingson et al.

NEUROTHERAPEUTICS (2017)

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Article Multidisciplinary Sciences

Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening

Sheng-Kai Wu et al.

SCIENTIFIC REPORTS (2017)

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Article Acoustics

Bolus versus Continuous Infusion of Microbubble Contrast Agent for Liver Ultrasound by Using an Automatic Power Injector in Humans: A Pilot Study

Emilio Quaia et al.

JOURNAL OF CLINICAL ULTRASOUND (2016)

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Article Oncology

Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival

Ryan Alkins et al.

NEURO-ONCOLOGY (2016)

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Review Radiology, Nuclear Medicine & Medical Imaging

Focused ultrasound-aided immunomodulation in glioblastoma multiforme: a therapeutic concept

Or Cohen-Inbar et al.

JOURNAL OF THERAPEUTIC ULTRASOUND (2016)

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Article Medicine, Research & Experimental

Focused ultrasound-induced blood-brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study

Pin-Yuan Chen et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

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Article Medicine, Research & Experimental

Contrast-Enhanced Ultrasound Imaging for the Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening

Ching-Hsiang Fan et al.

THERANOSTICS (2014)

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Article Oncology

Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

Mark R. Gilbert et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

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Article Multidisciplinary Sciences

Tumor radiation response enhancement by acoustical stimulation of the vasculature

Gregory J. Czarnota et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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