期刊
JOURNAL OF NEURAL ENGINEERING
卷 19, 期 3, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1741-2552/ac6f80
关键词
retinal prosthesis; chick retina; photoreceptor replacement
资金
- JC Bose Fellowship of Department of Science and Technology, India
Interfacing optoelectronic semiconducting polymer material with a blind-developing chick retina allows for a response similar to natural photoreceptors. By recording evoked action potentials, the changing characteristics of the signal during different stages of retina development can be observed, highlighting the emerging network pathways in the vision process of the artificial photoreceptor interfaced retina.
Optoelectronic semiconducting polymer material interfaced with a blind-developing chick-retina (E13-E18) in subretinal configuration reveals a response to full-field flash stimulus that resembles an elicited response from natural photoreceptors in a neonatal chick retina. The response manifests as evoked-firing of action potentials and was recorded using a multi-electrode array in contact with the retinal ganglion layer. Characteristics of increasing features in the signal unfold during different retina-development stages and highlight the emerging network mediated pathways typically present in the vision process of the artificial photoreceptor interfaced retina.
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