Complex Flavanones from Cryptocarya metcalfiana and Structural Revision of Oboflavanone A

Nine new complex flavanones, cryptometcones A-I (1-9), along with four known analogues, were isolated from Cryptocarya metcalfiana. The structures of 1-9 including their absolute configurations were elucidated by spectroscopic data analysis and electronic circular dichroism (ECD) calculations. In addition, the structure of oboflavanone A was revised, while the absolute configurations of oboflavanone B, cryptoflavanone C, and cryptoflavanone D were determined, according to their spectroscopic data. Compounds 3-5, 8, and 9 exhibited cytotoxicity against the HCT-116 cancer cell line.

Automated summary

Nine new complex flavanones, named cryptometcones A-I (1-9), along with four known analogues, were isolated from Cryptocarya metcalfiana. Their structures and absolute configurations were determined through spectroscopic data analysis and ECD calculations. Compounds 3-5, 8, and 9 exhibited cytotoxicity against the HCT-116 cancer cell line.