相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors
Yan Sun et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2021)
Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant
Tsutomu Fukuda et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2021)
Olmutinib in T790M-positive non-small cell lung cancer after failure of first-line epidermal growth factor receptor-tyrosine kinase inhibitor therapy: A global, phase 2 study
Keunchil Park et al.
CANCER (2021)
Evaluation of the binding behavior of olmutinib (HM61713) with model transport protein: Insights from spectroscopic and molecular docking studies
Song-Bo Kou et al.
JOURNAL OF MOLECULAR STRUCTURE (2021)
Design, synthesis, characterization, molecular docking and computational studies of 3-phenyl-2-thioxoimidazolidin-4-one derivatives
U. Vanitha et al.
JOURNAL OF MOLECULAR STRUCTURE (2021)
Novel thienopyrimidine analogues as potential metabotropic glutamate receptors inhibitors and anticancer activity: Synthesis, In-vitro, In-silico, and SAR approaches
Mohammed A. Khedr et al.
BIOORGANIC CHEMISTRY (2021)
A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells
Diwakar Bastihalli Tukaramrao et al.
CANCERS (2021)
Therapeutic Potential, Synthesis, Patent evaluation and SAR studies of thieno[3,2-d]pyrimidine derivatives: Recent updates.
Farhana Islam et al.
CURRENT DRUG TARGETS (2021)
Design, Synthesis, and Antitumor Activity of Olmutinib Derivatives Containing Acrylamide Moiety
Xiaohan Hu et al.
MOLECULES (2021)
New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053
Laurent R. Chiarelli et al.
ACS INFECTIOUS DISEASES (2020)
Discovery of new thieno[3,2-d]pyrimidine derivatives targeting EGFRL858R/T790M NSCLCs by the conformation constrained strategy
Yang Chen et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors
Zhen Xiao et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations
Zhen Xiao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio- thienopyrimidine (TTP) series of antimalarials
Robert D. Barrows et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Thieno[2,3-d] pyrimidine as a promising scaffold in medicinal chemistry: Recent advances
Eslam M. H. Ali et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies
Mai S. El-Shoukrofy et al.
BIOORGANIC CHEMISTRY (2019)
Efficient Synthesis and Biological Evaluation of 2,4-Diaminothieno[2,3-d]pyrimidine Derivative
Na Hou et al.
CHEMISTRYSELECT (2019)
Synthesis and molecular docking study of some 3,4-dihydrothieno[2,3-d]pyrimidine derivatives as potential antimicrobial agents
Omaima G. Shaaban et al.
BIOORGANIC CHEMISTRY (2019)
Synthesis and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines of Thieno[2,3-d]pyrimidine Derivatives containing Isoxazole Moiety
Jianping Yong et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2018)
Olmutinib-induced palmoplantar keratoderma
K. L. Chen et al.
BRITISH JOURNAL OF DERMATOLOGY (2018)
Design, Synthesis, and Biological Activity of Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine Derivatives as Anti-Inflammatory Agents
Yuan Zhang et al.
MOLECULES (2017)
Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists
Yoon Kyung Jang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles
Dongwei Kang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Thiophene-expanded guanosine analogues of Gemcitabine
Zhe Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis
Theodosia Teo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
James A. Maier et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
Efficient Synthesis of New Thieno[2,3-d]pyrimidin-4(3H)-one Derivatives for Evaluation as Anticancer Agents
Yang-Gen Hu et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2014)
Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives acting as antimicrobial agents
Shrikant B. Kanawade et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Synthesis and evaluation of anticonvulsant and antidepressant activities of 5-alkoxytetrazolo[1,5-c]thieno[2,3-e]pyrimidine derivatives
Shi-Ben Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes
Jifeng Deng et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations
Tingjun Hou et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Efficient synthesis and biological evaluation of some 2,4-diamino-furo[2,3-d]pyrimidine derivatives
Yang-Gen Hu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Synthesis of substituted thieno[2,3-d]pyrimidine-2,4-dithiones and their S-glycoside analogues as potential antiviral and antibacterial agents
Hend N. Hafez et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Selectivity of Neutral/Weakly Basic P1 Group Inhibitors of Thrombin and Trypsin by a Molecular Dynamics Study
Emilia L. Wu et al.
CHEMISTRY-A EUROPEAN JOURNAL (2008)
Modeling the catalysis of anti-cocaine catalytic antibody: Competing reaction pathways and free energy barriers
Yongmei Pan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Quantum and molecular dynamics study for binding of macrocyclic inhibitors to human alpha-thrombin
Emilia L. Wu et al.
BIOPHYSICAL JOURNAL (2007)
A modified TIP3P water potential for simulation with Ewald summation
DJ Price et al.
JOURNAL OF CHEMICAL PHYSICS (2004)