Structure and toxicity of N-donor thionate Zn complexes

The reaction of thiosaccharin (thiosaccharin: the thione form of saccharin) and N-donor bases with Zn2+ yielded three new thionate complexes: [Zn(tsac)(2)(imidazole)(2)], [Zn(tsac)(2)(benzimidazole)(2)]center dot H2O and [Zn(tsac)(2)(2-methylimidazole)(2)]center dot 2 H2O (tsac: thiosaccharinate, C6H4C(S)NSO2). The new complexes were characterized employing Fourier Transform Infrared Spectroscopy (FTIR) and elemental analysis (EA). [Zn(tsac)(2)(imidazole)(2)] and [Zn(tsac)(2)(benzimidazole)(2)]center dot H2O crystal structures were determined with the aid of single crystal X-ray diffraction analysis (XRD). Both complexes exhibit a tetrahedral S2N2Zn environment, with the thiosaccharinate anions coordinated through their exocyclic Sulphur atoms. The structure of [Zn(tsac)(2)(2-methylimidazole)(2)]center dot 2H(2)O was proposed based on spectroscopic analysis. Moreover, a study on the effects of the three coordination compounds on erythrocyte sedimentation rate and osmotic fragility of red blood cells were held. Results revealed that these compounds at concentrations up to 10 mu g/mL do not affect the activity of pro-sedimentation and anti-sedimentation factors. Only [Zn(tsac)(2)(2-methylimidazole)(2)]center dot 2H(2)O at 10 mu g/mL induced fragility on red blood cells membrane. (c) 2021Elsevier B.V. All rights reserved.

Automated summary

The reaction of thiosaccharin and N-donor bases with Zn2+ formed three new thionate complexes. The crystal structures and characteristics of these complexes were determined using FTIR and EA. The study revealed that these compounds have limited effects on erythrocyte sedimentation rate and osmotic fragility.