期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1265, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molstruc.2022.133395
关键词
Metrosideros polymorpha; Pentacyclic triterpenoid; Antifungal activity; Insecticidal activity; GDH inhibitors
资金
- National Natural Science Foundation of China [31470414, 31870332]
- Spe-cial Fund Project of Shenzhen City for Local Science and Technol-ogy development Guided by Central Government [2021Szvup049]
- Interdisciplinary integration innovation project of Jilin University [2060302]
- National Major Increase or Decrease Project Construction of the sustainable utilization capacity of famous traditional Chinese medicine resources
Eleven compounds were isolated from M. polymorpha, including a previously undescribed compound and ten known compounds. The structures of compound 1 were determined and identified as pentacyclic triterpenoid derivative. Compound 7 showed significant antifungal and insecticidal activity.
Eleven compounds were isolated and identified from M. polymorpha , included one previously undescribed compound ( 1 ) and ten known compounds ( 2-11 ). Through NMR, HRESI-MS and ECD spectrum analysis, the planar and absolute structures of compound 1 were determined and identified as pentacyclic triterpenoid derivative. Among the rest 10 known compounds, 2-8 also were identified as pentacyclic triterpenoids. The antifungal, insecticidal activity and Glutamate dehydrogenase (GDH) inhibitory activity of the 11 compounds isolated from M. polymorpha were evaluated, and arjunolic acid ( 7 ) showed significant antifungal activity against hizoctonia solani and Magnaporthe oryzae with IC 50 values 44.20 and 38.58 mu g mL -1 , respectively. Moreover, compound 7 displayed insecticidal activity against whitefly at a 100 mu g mL -1 concentration with corrected mortality of 35.4%. In addition, compounds 2, 3, 4, 7 and 8 exhibited strong GDH inhibitory effects at both 20 and 50 mu M, and compound 4 showed the most effective activity. The underlying inhibitory mechanism of compound 4 against GDH was confirmed as competitive inhibitors through molecular docking and enzyme kinetics. These results may lead to a potential application on agricultural and clinical use.
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