4.2 Article

Design of imprinting matrix for dual template sensing via electropolymerized polythiophene films

期刊

JOURNAL OF MOLECULAR RECOGNITION
卷 35, 期 8, 页码 -

出版社

WILEY
DOI: 10.1002/jmr.2962

关键词

3-thiophene acetic acid; antipyrine; dual drug imprinting; ethionamide; MIP sensor; molecularly imprinted polymer

资金

  1. IoE, Banaras Hindu University
  2. Department of Science and Technology, Ministry of Science and Technology, India
  3. University Grants Commission

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This study presents the design of a sensor based on a 3-thiophene acetic acid polymer matrix and reduced graphene oxide composite for simultaneous detection of antipyrine and ethionamide. The sensor exhibits high sensitivity and selectivity for the targeted drug molecules even at low concentrations.
This work presents the design of 3-thiophene acetic acid (3-TAA) polymer matrix based molecularly imprinted polymer (MIP)/reduced graphene oxide (RGO) composite for sensitive and selective detection of antipyrine (AnP) and ethionamide (ETH) simultaneously. Dual drug embedded molecularly imprinted polymer (MIP) based electrochemical sensor was developed via electropolymerization of 3-TAA. AnP and ETH were embedded inside a polymer matrix based on their 3-D orientation and interaction(s) with functional monomer(s). Their extraction from polymeric matrix generates cavities complimentary to shape and size of AnP and ETH. The extraction of templates was confirmed by differential pulse voltammetry (DPV) as well as high-performance liquid chromatography (HPLC). The designed sensor selectively captures and produces the electrochemical signal for imprinted drugs. The electrochemical behaviour of AnP and ETH was investigated by DPV technique. The sensitivity for both drug molecules was commendable on a single polymeric composite with RGO on GC electrode (LOD of 0.117 mu M for AnP and 0.15 mu M for ETH). Also, the sensor exhibited excellent selectivity towards AnP and ETH in the presence of other analogous interferent molecules. Thus, the designed sensor showed high sensitivity as well as high selectivity for imprinted dual drug molecules on a single platform.

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