Synthesis and aggregation behavior of novel biosurfactants choline cholate and choline deoxy cholate

Herein, we report the synthesis and interfacial properties of cholesterol based biocompatible surfaceactive biosurfactant choline cholate (CC) and choline deoxy cholate (CDC) surfactants, prepared through salt metathesis reaction. The surface activity and aggregation behavior of these surfactants were investigated by surface tension measurements and small angle X-ray scattering (SAXS) technique. CC and CDC both formed well-defined micelles with distinct CMC values as indicated by tensiometry, while the SAXS patterns can be well described by the polydisperse ellipsoid model. Furthermore, it was observed that both CC and CDC showed good foamability ascribed to the foam film rigidity which could be highly beneficial. Also, CC and CDC showed sphere-to rod micellar transition in the presence of CTAB. The study reported here may prove to be highly beneficial for pharmaceutical and personal care product formulations. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

In this study, the synthesis and interfacial properties of choline cholate (CC) and choline deoxy cholate (CDC) surfactants prepared through salt metathesis reaction were reported. The experiments showed that both CC and CDC formed well-defined micelles and exhibited good foamability in the presence of CTAB. The findings of this study are of great importance for the formulation design of pharmaceutical and personal care products.