相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Microglial? signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome
Katharina Cosker et al.
SCIENTIFIC REPORTS (2021)
Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
Benjamin J. Andreone et al.
NATURE NEUROSCIENCE (2020)
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
Justin M. Long et al.
CELL (2019)
Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities
Hailan Yao et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Neurodegenerative Disease-Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain
Hunter B. Dean et al.
FRONTIERS IN NEUROLOGY (2019)
Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk
Dervis A. Salih et al.
BRAIN COMMUNICATIONS (2019)
Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes
Carmen Mecca et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline
Jorge L. Del-Aguila et al.
JOURNAL OF ALZHEIMERS DISEASE (2018)
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
Yingjun Zhao et al.
NEURON (2018)
Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models
C. Y. Daniel Lee et al.
NEURON (2018)
Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases
Hiroyuki Konishi et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2018)
High-affinity interactions and signal transduction between A beta oligomers and TREM2
Christian B. Lessard et al.
EMBO MOLECULAR MEDICINE (2018)
New insights into the role of TREM2 in Alzheimer's disease
Maud Gratuze et al.
MOLECULAR NEURODEGENERATION (2018)
ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans
Olivia J. Conway et al.
MOLECULAR NEURODEGENERATION (2018)
Microglia in Alzheimer's disease
Heela Sarlus et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca Sims et al.
NATURE GENETICS (2017)
EVIDENCE OF CNS β-AMYLOID DEPOSITION IN NASU-HAKOLA DISEASE DUE TO THE TREM2 Q33X MUTATION
Laura Ghezzi et al.
NEUROLOGY (2017)
Elucidating the Role of TREM2 in Alzheimer's Disease
Jason D. Ulrich et al.
NEURON (2017)
ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157
Dominik Feuerbach et al.
NEUROSCIENCE LETTERS (2017)
TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant
Peter Thornton et al.
EMBO MOLECULAR MEDICINE (2017)
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
Kai Schlepckow et al.
EMBO MOLECULAR MEDICINE (2017)
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease
Tyler K. Ulland et al.
CELL (2017)
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
Hadas Keren-Shaul et al.
CELL (2017)
Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation
Wilbur Song et al.
ALZHEIMERS & DEMENTIA (2017)
Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility
Guiyou Liu et al.
MOLECULAR NEUROBIOLOGY (2016)
Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains
Li Ma et al.
MOLECULAR NEURODEGENERATION (2016)
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
Marco Colonna et al.
NATURE REVIEWS NEUROSCIENCE (2016)
Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation
Honghua Zheng et al.
NEUROBIOLOGY OF AGING (2016)
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
Peng Yuan et al.
NEURON (2016)
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
Felix L. Yeh et al.
NEURON (2016)
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice
Teng Jiang et al.
NEUROPHARMACOLOGY (2016)
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
Daniel L. Kober et al.
ELIFE (2016)
Triggering receptor expressed on myeloid cells-2 fine-tunes inflammatory responses in murine Gram-negative sepsis
Riem Gawish et al.
FASEB JOURNAL (2015)
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
Taylor R. Jay et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
TREM2 is associated with increased risk for Alzheimer's disease in African Americans
Sheng Chih Jin et al.
MOLECULAR NEURODEGENERATION (2015)
Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease
Atsushi Sasaki et al.
NEUROGENETICS (2015)
Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus
Ji-Seon Park et al.
TRAFFIC (2015)
A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology
Mar Matarin et al.
CELL REPORTS (2015)
R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family Clinical, Genetic, and Neuropathological Study
Olena Korvatska et al.
JAMA NEUROLOGY (2015)
Coding variants in TREM2 increase risk for Alzheimer's disease
Sheng Chih Jin et al.
HUMAN MOLECULAR GENETICS (2014)
Increased Expression of TREM2 in Peripheral Blood of Alzheimer's Disease Patients
Nan Hu et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Lack of Genetic Association Between TREM2 and Late-Onset Alzheimer's Disease in a Japanese Population
Akinori Miyashita et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Ye Zhang et al.
JOURNAL OF NEUROSCIENCE (2014)
Frontobasal gray matter loss is associated with the TREM2 p.R47H variant
Elkin O. Luis et al.
NEUROBIOLOGY OF AGING (2014)
Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease
Teng Jiang et al.
NEUROPSYCHOPHARMACOLOGY (2014)
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
Gernot Kleinberger et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
TREM2 Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis
Janet Cady et al.
JAMA NEUROLOGY (2014)
Mammalian Phospholipase C
Ganesh Kadamur et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)
TREM2 R47H Variant as a Risk Factor for Early-Onset Alzheimer's Disease
Cyril Pottier et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage
Patrick Wunderlich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Insights into TREM2 biology by network analysis of human brain gene expression data
Paola Forabosco et al.
NEUROBIOLOGY OF AGING (2013)
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
Thorlakur Jonsson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
TREM2 Variants in Alzheimer's Disease
Rita Guerreiro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
OSTEODYSPLASIA POLYCYSTICA HEREDITARIA COMBINED WITH SCLEROSING LEUCOENCEPHALOPATHY
H. P. A. Hakola et al.
ACTA NEUROLOGICA SCANDINAVICA (2010)
Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia
Norifumi Shioda et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Activating and inhibitory functions of DAP12
Isaiah R. Turnbull et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
Attila Mocsai et al.
NATURE IMMUNOLOGY (2006)
Cutting edge: TREM-2 attenuates macrophage activation
Isaiah R. Turnbull et al.
JOURNAL OF IMMUNOLOGY (2006)
Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
Jessica A. Hamerman et al.
JOURNAL OF IMMUNOLOGY (2006)
Role of genes and environments for explaining Alzheimer disease
M Gatz et al.
ARCHIVES OF GENERAL PSYCHIATRY (2006)
The genetic causes of basal ganglia calcification, dementia, and bone cysts DAP12 and TREM2
HH Klünemann et al.
NEUROLOGY (2005)
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
K Takahashi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Pattern recognition by TREM-2: Binding of anionic ligands
MR Daws et al.
JOURNAL OF IMMUNOLOGY (2003)
The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44
RJN Allcock et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
J Paloneva et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2002)
Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
A Bouchon et al.
JOURNAL OF IMMUNOLOGY (2000)