4.4 Article

Suppression of Adipogenesis and Fat Accumulation by Vitexin Through Activation of Hedgehog Signaling in 3T3-L1 Adipocytes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cardiac & Cardiovascular Systems

Obesity and Coronary Heart Disease: Epidemiology, Pathology, and Coronary Artery Imaging

Natraj Katta et al.

Summary: Overweight and obesity contribute to cardiovascular disease, especially coronary heart disease, partly by their association with traditional and nontraditional risk factors. Obesity is also considered an independent risk factor for CVD. There is abundant epidemiologic evidence of an association between overweight, obesity, and CHD.

CURRENT PROBLEMS IN CARDIOLOGY (2021)

Article Cell Biology

Garcinia cambogia suppresses adipogenesis in 3T3-L1 cells by inhibiting p90RSK and Stat3 activation during mitotic clonal expansion

Joo-Hui Han et al.

Summary: This study demonstrated thatGarcinia cambogiaextract inhibited mitotic clonal expansion (MCE) by regulating p90RSK, Stat3, and cell cycle proteins, leading to G(0)/G(1) arrest. These findings provide new insight into the mechanism by whichG.cambogiasuppresses adipocyte differentiation and show that p90RSK is critical for adipogenesis as a new molecular target.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Review Physiology

Hedgehog Signaling in Intestinal Development and Homeostasis

Katherine D. Walton et al.

Summary: The Hedgehog (Hh) signaling pathway plays crucial regulatory and patterning roles during intestine organogenesis and homeostasis in adults, with Hh ligands expressed in the endodermally derived epithelium and signal transduction confined to the mesenchymal compartment. This leads to a feedback loop where epithelial Hh ligands regulate mesenchymal cell behaviors and guide them to secrete additional soluble factors that in turn regulate epithelial cells. The evolutionary conservation of this pathway and epithelial/mesenchymal crosstalk in the intestine has contributed to our understanding of its role in intestinal organogenesis.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 83 (2021)

Review Biochemistry & Molecular Biology

Sonic hedgehog signaling in astrocytes

Steven A. Hill et al.

Summary: Astrocytes are complex cells performing essential functions in the nervous system. The Sonic hedgehog (Shh) signaling pathway plays a crucial role in regulating the molecular identity and functional properties of astrocytes, and is active in specific subpopulations of these cells throughout the brain.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Gastroenterology & Hepatology

AICAR and compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro

Katrin Bottcher et al.

Summary: The tumor stroma and microenvironment influence hepatocellular carcinoma (HCC) growth, with activated hepatic stellate cells (HSC) playing a significant role. Recent research suggests that AMPK may mediate crucial processes during carcinogenesis and HCC progression. Different HCC cell lines affect human hepatic stellate cell (hHSC) proliferation and AMPK activity in varying ways through paracrine signaling, and pharmacological treatment can inhibit HCC-induced hHSC activation through multiple mechanisms involving AMPK. Data analysis shows that the expression of AMPK alpha 1 and alpha 2 differs based on mutations, tumor grading, and classification in human HCC.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

Article Biochemistry & Molecular Biology

Tm7sf2 gene promotes adipocyte differentiation of mouse embryonic fibroblasts and improves insulin sensitivity

Leonardo Gatticchi et al.

Summary: Adipogenesis is regulated by a transcriptional cascade involving CEBP and PPAR family members and hormonally induced pathways. Tm7sf2 gene is involved in cholesterol biosynthesis and modulates the expression of the master gene of adipogenesis PPAR gamma, affecting adipose tissue homeostasis. Loss of Tm7sf2 impairs adipocyte differentiation by affecting adipogenic regulators and insulin signaling, indicating its importance in maintaining metabolic health.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Functional crosstalk between myeloid Foxo1-β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response

Changyong Li et al.

Summary: The study demonstrates that myeloid-specific Foxo1 knockout mice are resistant to oxidative stress-induced liver injury by enhancing beta-catenin-mediated Gli1/Snail signaling, reducing inflammation, and inhibiting necroptosis. The colocalization of Foxo1 and beta-catenin in macrophages leads to the activation of Gli1/Snail signaling and suppression of RIPK3 and NEK7/NLRP3 expression under inflammatory conditions. Disruption of this axis exacerbates liver damage, leading to increased necroptosis and inflammatory response.

CELL DEATH AND DIFFERENTIATION (2021)

Article Endocrinology & Metabolism

Hedgehog signaling in endocrine and folliculo-stellate cells of the adult pituitary

Dominik Simon Botermann et al.

Summary: The activation of the Hedgehog signaling pathway influences the homeostasis of pituitary hormone production by regulating growth hormone production and secretion through folliculo-stellate cells.

JOURNAL OF ENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products

Jelena Jakab et al.

Summary: Obesity poses a serious threat to human health, with adipogenesis being a possible therapeutic approach. Natural products have been studied for their inhibitory effects on adipocyte differentiation and lipid accumulation, which may include inducing apoptosis.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

Review Oncology

FGF21 in obesity and cancer: New insights

Weiqin Lu et al.

Summary: FGF21 is a novel metabolic regulator that acts as a stress sensor in tissues like the liver, promoting metabolic homeostasis through pathways that encourage lipid catabolism. Its signal pathway targets white and brown adipose tissues, playing a key role in preventing the development of diseases like fatty pancreas and steato-hepatitis.

CANCER LETTERS (2021)

Article Plant Sciences

Caudatin suppresses adipogenesis in 3T3-L1 adipocytes and reduces body weight gain in high-fat diet-fed mice through activation of hedgehog signaling

Shuai Qiu et al.

Summary: The study demonstrated that the C-21 steroid caudatin inhibits adipogenesis and obesity by activating the Hh signaling pathway, reducing lipid accumulation and body weight gain.

PHYTOMEDICINE (2021)

Review Neurosciences

Cilia, ciliopathies and hedgehog-related forebrain developmental disorders

Abraham Andreu-Cervera et al.

Summary: Development of the forebrain heavily relies on the Sonic Hedgehog (Shh) signaling pathway and functional primary cilia. Dysfunction of cilia may lead to ciliopathies, affecting multiple organs and potentially causing forebrain malformations. Therefore, further research is needed to investigate the relationship between forebrain defects in ciliopathies and the disruption of the Shh pathway.

NEUROBIOLOGY OF DISEASE (2021)

Review Cell Biology

Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis

Twan J. J. de Winter et al.

Summary: Wnt/β-catenin signaling pathway plays a role in suppressing differentiation of MSCs into adipocytes, promoting cell proliferation, and later promoting osteogenesis. Studies have shown that during the differentiation of MSCs into preadipocytes, Wnt signaling is regulated by endogenous Wnt inhibitors.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

MEVITEM-a phase I/II trial of vismodegib plus temozolomide vs temozolomide in patients with recurrent/refractory medulloblastoma with Sonic Hedgehog pathway activation

Didier Frappaz et al.

Summary: The study evaluated the treatment of SHH recurrent/refractory adult medulloblastoma with vismodegib + temozolomide and found no improvement in 6-month progression-free survival. Further refinements are needed for predicting sensitivity to vismodegib.

NEURO-ONCOLOGY (2021)

Review Oncology

GLI1: A Therapeutic Target for Cancer

Justin T. Avery et al.

Summary: GLI1, a transcriptional effector in the Hedgehog signaling pathway, is tightly regulated during normal tissue development but aberrant activation in cancer can promote hallmarks such as proliferation, metastasis, and chemoresistance. Its oncogenic activities mainly involve regulating cell cycle, DNA replication, and DNA damage repair processes. Understanding the mechanisms of GLI1 dysregulation can provide prognostic and diagnostic biomarkers for targeted therapy in cancer treatment.

FRONTIERS IN ONCOLOGY (2021)

Article Ophthalmology

Hedgehog Signaling Pathway Regulates the Proliferation and Differentiation of Rat Meibomian Gland Epithelial Cells

Jing-Yu Qu et al.

Summary: The Hedgehog signaling pathway plays an important role in regulating proliferation and differentiation of RMGECs, potentially offering a therapeutic approach for treating meibomian gland dysfunction (MGD).

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021)

Article Cell Biology

Hedgehog Signaling Modulates Glial Proteostasis and Lifespan

Andrew Rallis et al.

CELL REPORTS (2020)

Article Andrology

Vitexin suppresses renal cell carcinoma by regulating mTOR pathways

Yuhong Li et al.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2020)

Article Behavioral Sciences

Astaxanthin protects cognitive function of vascular dementia

Ningwei Zhu et al.

BEHAVIORAL AND BRAIN FUNCTIONS (2020)

Article Medicine, Research & Experimental

FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells

Yuan Zhong et al.

LIFE SCIENCES (2020)

Review Cell Biology

Epigenetics in Human Obesity and Type 2 Diabetes

Charlotte Ling et al.

CELL METABOLISM (2019)

Article Plant Sciences

Cynometra cauliflora Linn. Attenuates metabolic abnormalities in high-fat diet-induced obese mice

Atefehalsadat Seyedan et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

Review Cell Biology

Adipogenesis and metabolic health

Alexandra L. Ghaben et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Agriculture, Multidisciplinary

Sulforaphene Inhibition of Adipogenesis via Hedgehog Signaling in 3T3-L1 Adipocytes

Jing Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Article Agriculture, Multidisciplinary

Potent Anti-Inflammatory and Antiadipogenic Properties of Bamboo (Sasa coreana Nakai) Leaves Extract and Its Major Constituent Flavonoids

Ji Hye Yang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

Q. Chen et al.

CELL DEATH AND DIFFERENTIATION (2016)

Review Biochemistry & Molecular Biology

Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules

Dorothy Moseti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Multidisciplinary Sciences

14-3-3ζ coordinates adipogenesis of visceral fat

Gareth E. Lim et al.

NATURE COMMUNICATIONS (2015)

Article Oncology

Hedgehog-GLI Signaling Inhibition Suppresses Tumor Growth in Squamous Lung Cancer

Lingling Huang et al.

CLINICAL CANCER RESEARCH (2014)

Article Pharmacology & Pharmacy

Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of monoaminergic mechanisms

Ozgur Devrim Can et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

Qiong A. Wang et al.

NATURE MEDICINE (2013)

Article Biochemistry & Molecular Biology

Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole-Induced Seizure in Rats

Esmail Abbasi et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2012)

Article Biochemistry & Molecular Biology

Reduced white fat mass in adult mice bearing a truncated Patched 1

Zili Li et al.

International Journal of Biological Sciences (2012)

Article Cell Biology

C/EBP alpha induces adipogenesis through PPAR gamma: a unified pathway

ED Rosen et al.

GENES & DEVELOPMENT (2002)