期刊
JOURNAL OF MEDICINAL FOOD
卷 25, 期 3, 页码 313-323出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2021.K.0163
关键词
adipocyte; adipogenesis; AMPK; hedgehog; vitexin
资金
- Korea National Research Foundation [NRF-2021R1F1A1063279]
- Bio-Synergy Research Project of Ministry of Science, ICT, and Futures Planning Besides [NRF-2013M3A9C4078156]
- Academic scholarship for College of Biotechnology and Natural Resources
- Chung-Ang University Graduate Research Scholarship
Studies have shown that vitexin can suppress adipogenesis by regulating the Hh signaling pathway and phosphorylation of AMPK, which leads to reduced lipid accumulation and obesity.
Many studies have demonstrated that adipogenesis is associated with obesity, and the Hedgehog (Hh) signaling pathway regulates adipogenesis and obesity. Following the screening study of the chemical library evaluating the effect of vitexin on Gli1 transcriptional activity, vitexin was chosen as a candidate for antiadipogenic efficacy. Vitexin significantly reduced lipid accumulation and suppressed C/EBP alpha (CCAAT/enhancer-binding protein alpha) and PPAR gamma (peroxisome proliferator-activated receptor gamma) expression, which are known as key adipogenic factors in the early stages of adipogenesis by activating Hh signaling. Furthermore, Hh inhibitor GANT61 reversed the effect of AMP-activated protein kinase (AMPK) activator AICAR (5-aminoimidazole-4-carboxamide ribonucleotide), indicating that Hh signaling is an upstream regulator of AMPK in 3T3-L1 cells. Vitexin suppressed adipogenesis by regulating Hh signaling and phosphorylation of AMPK, leading to the inhibition of fat formation. These results suggest that vitexin can be considered a potent dietary agent in alleviating lipid accumulation and obesity.
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