Development of Azaindole-Based Frameworks as Potential AntiviralAgents and Their Future Perspectives

The azaindole (AI) framework continues to play asignificant role in the design of new antiviral agents. Modulating theposition and isosteric replacement of the nitrogen atom of AI analogsnotably influences the intrinsic physicochemical properties of leadcompounds. The intra- and intermolecular interactions of AIderivatives with host receptors or viral proteins can also befinetuned by carefully placing the nitrogen atom in the heterocyclic core.This wide-ranging perspective article focuses on AIs that haveconsiderable utility in drug discovery programs against RNA viruses.The inhibition of influenza A, human immunodeficiency, respiratorysyncytial, neurotropic alpha, dengue, ebola, and hepatitis C viruses by AI analogs is extensively reviewed to assess their plausiblefuture potential in antiviral drug discovery. The binding interaction of AIs with the target protein is examined to derive a structuralbasis for designing new antiviral agents.

Automated summary

The azaindole (AI) framework plays a significant role in designing antiviral agents by modulating the position and replacement of the nitrogen atom. The interactions of AI derivatives with host receptors or viral proteins can be finely tuned by carefully placing the nitrogen atom. This perspective article focuses on the utility of AI in drug discovery against RNA viruses, reviewing the inhibition of various viruses and examining the binding interaction with target proteins to guide the design of new antiviral agents.