期刊
JOURNAL OF MEDICAL VIROLOGY
卷 94, 期 9, 页码 4338-4347出版社
WILEY
DOI: 10.1002/jmv.27826
关键词
cross infection; dengue virus; pathogenicity
类别
资金
- National Natural Science Foundation of China [31970868, 31860256]
- Technology Talents Training Project of the Kunming Health Science Bureau [2018-SW-8]
- Scientific Research Fund project of the Yunnan Education Department [2019J0507]
- Peking Union Medical College-Youth Research Fund [3332015052]
- Key Research and Development Plans of Yunnan Province [2019ZF004]
- Applied Basic Research Programs of Yunnan Province [2018FB129]
The study investigates the risk of cross infection and severity of dengue virus in BALB/c mice, particularly focusing on the impact of maternal immunity and heterotypic infection. The results suggest that maternal immunity enhances subsequent heterotypic infection and can lead to severe disease. This study has implications for understanding cross infection and vaccine development.
Dengue virus (DV) has occasionally emerged at epidemic levels in Yunnan, China. Vaccine development is limited by antibody-dependent enhancement and a lack of good animal models. Thus, the study investigated cross infection based on maternal immunity in BALB/c mice and assessed the risk of cross infection by DV2-D13113 and DV3-YNWS2 epidemic virus strains. DV replicated within the organs of the BALB/c infant mice, even causing death. Particularly, DV3-infected infant mice were at higher risk of severe disease if their mothers were infected with DV2. Although BALB/c adults and pups survived DV2/DV3 infection and produced anti-DV antibodies after 5-8 days, extensive subcutaneous vascular leakage was observed after secondary DV infection. Furthermore, vascular permeability in the lung and kidney significantly increased in offspring born to heterotypic virus-infected mothers. Thus, vascular leakage indicates severe DV infection. The results indicate that maternal immunity increases the severity of subsequent heterotypic infection. Additionally, secondary cross infection by D13113 and YNWS2 represents a risk of serious disease. This study has implications for studies of DV cross infection and vaccine development.
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