期刊
JOURNAL OF MEDICAL VIROLOGY
卷 94, 期 8, 页码 3992-3997出版社
WILEY
DOI: 10.1002/jmv.27811
关键词
neutralization; Omicron variant; RBD vaccine; SARS-CoV-2; sequential immunization
类别
资金
- National Science Fund for Distinguished Young Scholars [82025022]
- National Natural Science Foundation of China [92169204, 82002140, 82171752, 82101861]
- National Key Plan for Scientific Research and Development of China [2021YFC0864500]
- Guangdong Basic and Applied Basic Research Foundation [2021B1515020034, 2021A1515011009, 2020A1515110656, 2019A1515011197]
- Shenzhen Science and Technology Program [RCYX20200714114700046]
- Science and Technology Innovation Committee of Shenzhen Municipality [JSGG20200207155251653, JSGG20200807171401008, JSGG202 10901145200002, KQTD20200909113758004]
- Shenzhen Natural Science Foundation [JCYJ20210324115611032, JCYJ2021 0324131606018, JCYJ20190809115617365]
This study demonstrates that using the Omicron BA.1 RBD as a fourth dose of vaccine can induce potent Omicron-specific neutralizing antibodies and exhibit broadly neutralizing activities against SARS-CoV-2 variants when used in sequential immunization.
The SARS-CoV-2 vaccines have been widely used to build an immunologic barrier in the population against the COVID-19 pandemic. However, a newly emerging Omicron variant, including BA.1, BA.1.1, BA.2, and BA.3 sublineages, largely escaped the neutralization of existing neutralizing antibodies (nAbs), even those elicited by three doses of vaccines. Here, we used the Omicron BA.1 RBD as a fourth dose of vaccine to induce potent Omicron-specific nAbs and evaluated the broadly neutralizing activities against SARS-CoV-2 variants. The BA.1-based vaccine was indeed prone to induce a strain-specific antibody response substantially cross-reactive with BA.2 sublineage, and yet triggered broad neutralization against SARS-CoV-2 variants when it was used in the sequential immunization with WT and other variant vaccines. These results demonstrated that the booster of Omicron RBD vaccine could be a rational strategy to enhance the broadly nAb response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据