期刊
JOURNAL OF MEDICAL VIROLOGY
卷 94, 期 8, 页码 3570-3580出版社
WILEY
DOI: 10.1002/jmv.27813
关键词
caspase-1; NLRP3 inflammasome; picornavirus; pyroptosis
类别
资金
- National Innovation and Entrepreneurship Training Program for college students [202110403093]
- National Natural Science Foundation of China [32060040, 31760261]
- Natural Science Foundation of Jiangxi Province [20202BAB206062]
- Training Plan for Academic and Technical Leaders of Major Disciplines in Jiangxi Province-Youth Talent Project [20212BCJ23036]
- Key research and development projects of Jiangxi Natural Science Foundation [20192BBG70067]
Cell pyroptosis plays a crucial role in viral infections, particularly in some picornavirus infections. However, excessive inflammasome activation or pyroptosis may harm the host's health or worsen disease progression.
Cell pyroptosis has received increased attention due to the associations between innate immunity and disease, and it has become a major focal point recently due to in-depth studies of cancer. With increased research on pyroptosis, scientists have discovered that it has an essential role in viral infections, especially in the occurrence and development of some picornavirus infections. Many picornaviruses, including Coxsackievirus, a71 enterovirus, human rhinovirus, encephalomyocarditis virus, and foot-and-mouth disease virus induce pyroptosis to varying degrees. This review summarized the mechanisms by which these viruses induce cell pyroptosis, which can be an effective defense against pathogen infection. However, excessive inflammasome activation or pyroptosis also can damage the host's health or aggravate disease progression. Careful approaches that acknowledge this dual effect will aid in the exploration of picornavirus infections and the mechanisms that produce the inflammatory response. This information will promote the development of drugs that can inhibit cell pyroptosis and provide new avenues for future clinical treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据