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Article
Biochemistry & Molecular Biology
Qianqian Li et al.
Summary: The 501Y.V2 variants of SARS-CoV-2 with multiple mutations are rapidly spreading from South Africa to other countries, showing reduced susceptibility to neutralizing antibodies and potential compromise of monoclonal antibodies and vaccines. Enhanced infectivity in murine ACE2-overexpressing cells suggests the possibility of transmission to mice.
Article
Biochemistry & Molecular Biology
Wilfredo F. Garcia-Beltran et al.
Summary: New variants of SARS-CoV-2 show high resistance to vaccine neutralization, with some able to escape vaccine responses with just a few mutations, highlighting the importance of developing broadly protective measures against variants.
Article
Virology
Yufei Zhang et al.
Summary: This study showed that aged BALB/c mice infected with SARS-CoV-2 exhibited rapid viral replication leading to pneumonia, while young mice quickly cleared the virus with no pathological changes in the lungs. Aged mice also had stronger cytokine responses, particularly interleukin 6 and interferon gamma, compared to young mice. The research further demonstrated the potential of using aged BALB/c mice as a model for understanding SARS-CoV-2 pathogenesis and testing vaccines and antiviral agents.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Houriiyah Tegally et al.
Summary: The article describes a newly emerged lineage of SARS-CoV-2, 501Y.V2, characterized by eight mutations in the spike protein, which may result in increased transmissibility or immune escape. This lineage originated in South Africa and quickly became dominant in Eastern Cape, Western Cape, and KwaZuluNatal provinces within weeks.
Article
Multidisciplinary Sciences
Nicholas G. Davies et al.
Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.
Article
Multidisciplinary Sciences
Shihui Sun et al.
Summary: The study presents a novel mouse-adapted SARS-CoV-2 strain, MASCp36, as a model for investigating the pathogenicity, evolution, and adaptation of the virus. Through deep sequencing and cryo-electron microscopy analysis, the molecular basis of structural changes and receptor binding mechanism at a biological level are revealed.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Antonio Muruato et al.
Summary: The study successfully generated a mouse-adapted strain of SARS-CoV-2 using a reverse genetic system, which recapitulates critical elements of human infection, including viral replication in the lung, immune cell infiltration, and significant in vivo disease.
Article
Biochemistry & Molecular Biology
Markus Hoffmann et al.
Summary: The emerging SARS-CoV-2 variants may exhibit resistance to existing neutralizing antibodies and treatments, which could have significant implications for pandemic containment efforts.
Article
Biochemistry & Molecular Biology
Xianding Deng et al.
Summary: A new SARS-CoV-2 variant named B.1.427/B.1.429 was identified in California, with increased transmissibility and carrying three mutations in spike protein, including L452R substitution. The variant emerged in May 2020 and became predominant in sequenced cases from September 2020 to January 2021. In vivo viral shedding was increased and antibody neutralization decreased, calling for further investigation.
Article
Immunology
Qiao Lu et al.
Summary: Multiple C-type lectins and TTYH2 were identified as glycan-dependent binding partners of SARS-CoV-2 spike, predominantly expressed on myeloid cells in the lungs of COVID-19 patients. Engagement of these receptors with the virus induced robust proinflammatory responses, correlating with disease severity. Targeting SARS-CoV-2-myeloid receptor interactions may provide potential therapeutic strategies for COVID-19.
Article
Medicine, General & Internal
Huiping Shuai et al.
Summary: The study found that the SARS-CoV-2 variant B.1.1.7 and other N501Y-carrying variants can infect wildtype mice and rats, producing high viral loads and infectious virus particles in their respiratory tract. This suggests that these variants may have evolved to expand species tropism to murines.
Letter
Virology
Qi Chen et al.
Article
Biology
Li Zhang et al.
Summary: Most SARS-CoV-2 variants exhibit slightly increased infectivity in human and monkey cell lines, with certain variants showing enhanced infectivity in specific cell types. Variants carrying specific amino acid mutations demonstrate increased abilities to infect certain cell types. Some variants show resistance to neutralization by antibodies and vaccines, primarily due to the E484K mutation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Immunology
Ruoke Wang et al.
Summary: Research shows that the South African B.1.351 variant exhibits the highest resistance to current monoclonal antibodies and convalescent plasma from COVID-19-infected individuals, and the molecular basis for this resistance and potential antibody escape has been identified.
Letter
Biochemistry & Molecular Biology
Jasdeep Singh et al.
Review
Genetics & Heredity
Kaiming Tao et al.
Summary: The emergence of multiple SARS-CoV-2 variants has significant impacts on the epidemiological and clinical aspects of the COVID-19 pandemic, including increased virus transmission rates, heightened risk of reinfection, and reduced effectiveness of neutralizing antibodies and vaccines. These variants have introduced new challenges to COVID-19 research, necessitating additional avenues of laboratory, epidemiological, and clinical studies.
NATURE REVIEWS GENETICS
(2021)
Review
Microbiology
William T. Harvey et al.
Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yongfei Cai et al.
Summary: The study found that the B.1.1.7 variant has increased receptor binding affinity, while the B.1.351 variant has developed resistance to some neutralizing antibodies by reshaping antigenic surfaces on the spike protein.
Editorial Material
Multidisciplinary Sciences
Qi Chen et al.
NATIONAL SCIENCE REVIEW
(2021)
Review
Medicine, General & Internal
Jun Yong Choi et al.
Summary: Since the beginning of the COVID-19 pandemic, the SARS-CoV-2 virus has evolved into various variants, with some designated as VOCs that have higher transmissibility and disease severity, potentially impacting vaccine effectiveness.
YONSEI MEDICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Peng Zhou et al.
Article
Microbiology
Michael Letko et al.
NATURE MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sarah R. Leist et al.
Article
Multidisciplinary Sciences
Hongjing Gu et al.
Letter
Cell Biology
Jinliang Wang et al.
Article
Multidisciplinary Sciences
Kenneth H. Dinnon et al.
