期刊
JOURNAL OF INTERNAL MEDICINE
卷 292, 期 1, 页码 146-153出版社
WILEY
DOI: 10.1111/joim.13479
关键词
cholesterol efflux; coronary heart disease; genome-wide association study; HDL; observational cohort study; triglycerides
资金
- EU
- Social Insurance Institution of Finland
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Foundation for Cardiovascular Research
- Finnish Cultural Foundation
- Sigrid Juselius Foundation
- Emil Aaltonen Foundation
- Yrjo Jahnsson Foundation
- Novo Nordisk Foundation
The association between HDL-CEC and CHD is inconsistent, and the genetic architecture of HDL-CEC is limited. In contrast to HDL-C, apolipoprotein A-I, and most HDL subclass particle concentrations, HDL-CEC is not unequivocally associated with CHD.
Background Observational findings for high-density lipoprotein (HDL)-mediated cholesterol efflux capacity (HDL-CEC) and coronary heart disease (CHD) appear inconsistent, and knowledge of the genetic architecture of HDL-CEC is limited. Objectives A large-scale observational study on the associations of HDL-CEC and other HDL-related measures with CHD and the largest genome-wide association study (GWAS) of HDL-CEC. Participants/methods Six independent cohorts were included with follow-up data for 14,438 participants to investigate the associations of HDL-related measures with incident CHD (1,570 events). The GWAS of HDL-CEC was carried out in 20,372 participants. Results HDL-CEC did not associate with CHD when adjusted for traditional risk factors and HDL cholesterol (HDL-C). In contradiction, almost all HDL-related concentration measures associated consistently with CHD after corresponding adjustments. There were no genetic loci associated with HDL-CEC independent of HDL-C and triglycerides. Conclusion HDL-CEC is not unequivocally associated with CHD in contrast to HDL-C, apolipoprotein A-I, and most of the HDL subclass particle concentrations.
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