期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 230, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2022.111748
关键词
Superoxide dismutase (SOD); Evolution; Pathogenesis; Metalloenzymes; Metal specificity; Manganese; Iron
资金
- National Institutes of Health [R01 AI155611, R21 AI149115]
- Vallee Scholar Award
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/S006818/1]
- BBSRC [BB/S006818/1] Funding Source: UKRI
Superoxide dismutases are ancient enzymes that are widely present in all domains of life. Recent studies on bacterial pathogens have challenged established dogmas and revealed the diverse repertoire and adaptive nature of SODs in response to hostile environments.
Superoxide dismutases (SODs) are ancient enzymes of widespread importance present in all domains of life. Many insights have been gained into these important enzymes over the 50 years since their initial description, but recent studies in the context of microbial pathogenesis have resulted in findings that challenge long established dogmas. The repertoire of SODs that bacterial pathogens encode is diverse both in number and in metal dependencies, including copper, copper and zinc, manganese, iron, and cambialistic enzymes. Other bacteria also possess nickel dependent SODs. Compartmentalization of SODs only partially explains their diversity. The need for pathogens to maintain SOD activity across distinct hostile environments encountered during infection, including those limited for essential metals, is also a driver of repertoire diversity. SOD research using pathogenic microbes has also revealed the apparent biochemical ease with which metal specificity can change within the most common family of SODs. Collectively, these studies are revealing the dynamic nature of SOD evolution, both that of individual SOD enzymes that can change their metal specificity to adapt to fluctuating cellular metal availability, and of a cell's repertoire of SOD isozymes that can be differentially expressed to adapt to fluctuating environmental metal availability in a niche.
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