期刊
JOURNAL OF INFECTION
卷 85, 期 1, 页码 49-56出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2022.05.012
关键词
multidrug-resistant tuberculosis; transmission; fitness-related genotypes; whole genome sequencing; compensatory; mutations
资金
- National Science and Tech-nology Major Project of China [2017ZX10201302, 2018ZX10715012]
- National Natural Science Foundation of China [81661128043, 81871625]
This study provides a global view of the correlation between common fitness-related genotypes and multidrug-resistant tuberculosis (MDR-TB) transmission. The results indicate that the factors commonly thought to increase bacterial fitness are not significantly associated with increased MDR-TB transmission.
Objectives: Environmental and host-related factors that contribute to the transmission of multidrugresistant tuberculosis (MDR-TB) have become an increasing concern, but the impact of bacterial genetic factors associated with bacterial fitness on MDR-TB transmission is poorly understood. Here, we present a global view of the correlation between common fitness-related genotypes and MDR-TB transmission by analyzing a representative number of MDR-TB isolates. Methods: We assembled a global whole genome sequencing (WGS) dataset of MDR-TB strains collected through retrospective cohorts or population-based approaches using public databases and literature curation. WGS-based clusters were defined as groups of strains with genomic difference of ??? 5 SNPs. Results: We curated high-quality WGS data of 4696 MDR-TB isolates from 17 countries with a mean clustering rate of 48% (range 0-10 0%). Correlational analysis showed that increased risk of MDR-TB strain clustering was not associated with compensatory mutations (OR 1.07, 95% CI 0.72-1.59), low-fitness cost drug-resistant mutations ( katG S315T: OR 1.42, 95% CI 0.82-2.47; rpoB S450L: OR 1.26, 95% CI 0.87-1.83) or Lineage 2 (OR 1.50, 95% CI 0.95-2.39). Conclusions: The factors most commonly thought to increase bacterial fitness were not significantly associated with increased MDR-TB transmission, and thus do not appear to be major contributors to the current epidemic of MDR-TB. ?? 2022 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据