期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 111, 期 -, 页码 121-128出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2022.03.042
关键词
Drug delivery; Magnetic tumor-targeting; Tumor microenvironment-responsive
资金
- National Research Foundation of Korea [4199990714708] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, tumor intracellular microenvironment-responsive nanoparticles were developed for tumor-targeted anti-cancer therapy and exhibited a contrast effect in magnetic resonance imaging.
Nanoparticles (NPs) with responsive modalities in biological microenvironments and external stimuli have received great attention as highly efficient and precise cancer therapy agents. In this study, tumor intracellular microenvironment-responsive NPs co-assembled from poly(ethylene glycol)-poly(aspartic acid) [PEG-P(Asp)] copolymer, doxorubicin (DOX), and superparamagnetic iron oxide NPs (SPIONs), termed as PEG-P(Asp)/DOX/SPIONs, were prepared for tumor intracellular microenvironment (enzyme and pH)-responsive and magnetically targeted chemotherapy. The NPs exhibited not only enzyme-responsive degradation in the presence of protease, but also triggered release of DOX at pH 5, which is an acidity similar to endolysosomal microenvironments in tumor cells. Furthermore, the PEG-P(Asp)/DOX/SPIONs showed a contrast effect in magnetic resonance imaging. In vitro viability assays showed that PEG-P (Asp)/DOX/SPIONs could effectively augment the cytocompatibility of DOX compared to free DOX without a change in magnetic forces. Fluorescence microscopy images indicated that the fabricated NPs efficiently increased the targeted uptake and release of DOX within cells. Overall, this hybrid NP system could be a favorable biomedical agent for effective tumor-targeted anti-cancer therapy. (c) 2022 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据