7-chloroquinoline-chalcone/-pyrazoline conjugates: Synthesis, antimycobacterial and cytotoxic activities

A series of 1H-1,2,3-triazole linked 7-chloroquinoline-chalcones and 7-chloroquinoline-pyrazolines were synthesized using 1,3-dipolar cycloaddition and evaluated for their antimycobacterial and cytotoxic activities. The compound having O-methoxy substituent on ring A and p-methoxy on ring B along with pyrazoline ring exhibited moderate activity and was noncytotoxic.

Automated summary

A series of 1H-1,2,3-triazole linked 7-chloroquinoline-chalcones and 7-chloroquinoline-pyrazolines were synthesized and evaluated for their antimycobacterial and cytotoxic activities. One compound with O-methoxy and p-methoxy substituents exhibited moderate activity and was noncytotoxic.