期刊
JOURNAL OF HEPATOLOGY
卷 76, 期 6, 页码 1263-1278出版社
ELSEVIER
DOI: 10.1016/j.jhep.2022.04.002
关键词
steatohepatitis; fibrosis; randomized controlled trials; non-invasive diagnosis; digital pathology; artificial intelligence; trial end-points; diabetes; obesity; cirrhosis; hepatocellular carcinoma
资金
- Gilead Sciences [1802154N]
- Intercept Pharmaceuticals
- Research Foundation Flanders (FWO)
- Astellas
- Falk Pharma
- Genfit
- GlympsBio
- Janssens Pharmaceutica
- Inventiva
- Merck Sharp Dome
- Pfizer
- Roche
- Sequana
- Bristol-Myers Squibb
- Merck
- Echosens
- Boehringer Ingelheim
- Galectin
- Novartis
- Salix
- Mallinckrodt
- Cumberland
- Gilead
Nonalcoholic steatohepatitis (NASH) has become a leading cause of chronic liver disease, and the need for effective treatments is urgent. Recent breakthroughs and progress in understanding the pathogenesis have set the stage for future therapeutic successes in NASH.
Initially a condition that received limited recognition and whose clinical impact was controversial, nonalcoholic steatohepatitis (NASH) has become a leading cause of chronic liver disease. Although there are no approved therapies, major breakthroughs, which will be reviewed here, have paved the way for future therapeutic successes. The unmet medical need in NASH is no longer disputed, and progress in the understanding of its pathogenesis has resulted in the identification of many pharmacological targets. Key surrogate outcomes for therapeutic trials are now accepted by regulatory agencies, thus creating a path for drug registration. A set of non-invasive measurements enabled early-stage trials to be conducted expeditiously, thus providing early indications on the biological and possibly clinical actions of therapeutic candidates. This generated efficacy results for a number of highly promising compounds that are now in late-stage development. Intense research aimed at further improving the assessment of histological endpoints and in developing non-invasive predictive biomarkers is underway. This will help improve the design and feasibility of successful trials, ultimately providing patients with therapeutic options that can change the course of the disease. (C) 2022 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据