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JOURNAL OF CLINICAL ONCOLOGY (2017)
Phase I First-in-Human Study of Venetoclax in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Matthew S. Davids et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas
Andrea Piunti et al.
NATURE MEDICINE (2017)
Proteasome inhibitors in cancer therapy
Elisabet E. Manasanch et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2017)
Marked for death: targeting epigenetic changes in cancer
Sophia Xiao Pfister et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
PI3Kδ inhibitor idelalisib in combination with BTK inhibitor ONO/GS-4059 in diffuse large B cell lymphoma with acquired resistance to PI3Kδ and BTK inhibitors
Anella Yahiaoui et al.
PLOS ONE (2017)
Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth
Hind Hashwah et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma
Jiyuan Zhang et al.
CANCER DISCOVERY (2017)
Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition
Joyoti Dey et al.
SCIENTIFIC REPORTS (2017)
Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma
Leo Meriranta et al.
HAEMATOLOGICA (2017)
CUDC-907 in relapsed/refractory diffuse large B-cell lymphoma, including patients with MYC-alterations: results from an expanded phase I trial
Yasuhiro Oki et al.
HAEMATOLOGICA (2017)
Strategies to Inhibit Myc and Their Clinical Applicability
Jonathan R. Whitfield et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2017)
The BET-Bromodomain Inhibitor JQ1 synergized ABT-263 against colorectal cancer cells through suppressing c-Myc-induced miR-1271-5p expression
Zhenqian Wu et al.
BIOMEDICINE & PHARMACOTHERAPY (2017)
Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor
Daisuke Honma et al.
CANCER SCIENCE (2017)
Tonic B-cell receptor signaling in diffuse large B-cell lymphoma
Ondrej Havranek et al.
BLOOD (2017)
A phase 2 study of mocetinostat, a histone deacetylase inhibitor, in relapsed or refractory lymphoma
Connie L. Batlevi et al.
BRITISH JOURNAL OF HAEMATOLOGY (2017)
AKT Hyperactivation and the Potential of AKT-Targeted Therapy in Diffuse Large B-Cell Lymphoma
Jinfen Wang et al.
AMERICAN JOURNAL OF PATHOLOGY (2017)
Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake
Xiuli Sim et al.
BLOOD (2017)
A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies
Shu-Hui Liu et al.
BLOOD ADVANCES (2017)
Venetoclax Synergizes with Radiotherapy for Treatment of B-cell Lymphomas
Shyril O'Steen et al.
CANCER RESEARCH (2017)
PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma
Lakshmi Nayak et al.
BLOOD (2017)
Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice
Idoia Garcia-Ramirez et al.
BLOOD (2017)
Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin-specific clinical impact
Daisuke Ennishi et al.
BLOOD (2017)
Molecular Subtyping in Diffuse Large B Cell Lymphoma: Closer to an Approach of Precision Therapy
Reem Karmali et al.
CURRENT TREATMENT OPTIONS IN ONCOLOGY (2017)
FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas
Maciej Szydlowski et al.
BLOOD (2016)
Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas
Ryan D. Morin et al.
CLINICAL CANCER RESEARCH (2016)
Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2-and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma
Magdalena Klanova et al.
CLINICAL CANCER RESEARCH (2016)
MYC/BCL6 double-hit lymphoma (DHL): a tumour associated with an aggressive clinical course and poor prognosis
Shaoying Li et al.
HISTOPATHOLOGY (2016)
Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma
Qing Ye et al.
ONCOTARGET (2016)
p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function
Zijun Y. Xu-Monette et al.
AGING-US (2016)
Phase 2 study of panobinostat with or without rituximab in relapsed diffuse large B-cell lymphoma
Sarit E. Assouline et al.
BLOOD (2016)
Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas
Konstantinos Georgiou et al.
BLOOD (2016)
The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow et al.
BLOOD (2016)
Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704
Soham D. Puvvada et al.
BRITISH JOURNAL OF HAEMATOLOGY (2016)
Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells
Michael Boice et al.
CELL (2016)
Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma
Zijun Y. Xu-Monette et al.
CLINICAL CANCER RESEARCH (2016)
Idelalisib for the treatment of non-Hodgkin lymphoma
Solomon A. Graf et al.
EXPERT OPINION ON PHARMACOTHERAPY (2016)
Kelch-like Protein 21 (KLHL21) Targets IB Kinase- to Regulate Nuclear Factor -Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively
Zhu-Zhong Mei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study
Alexander M. Lesokhin et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
Bromodomain 4: a cellular Swiss army knife
Ballachanda N. Devaiah et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2016)
Quadruplex Nucleic Acids as Novel Therapeutic Targets
Stephen Neidle
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Safety, tolerability, and preliminary activity of CUDC-907, a first-in-class, oral, dual inhibitor of HDAC and PI3K, in patients with relapsed or refractory lymphoma or multiple myeloma: an open-label, dose-escalation, phase 1 trial
Anas Younes et al.
LANCET ONCOLOGY (2016)
JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma
M-L Nairismagi et al.
LEUKEMIA (2016)
BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members
Simon J. Hogg et al.
MOLECULAR CANCER THERAPEUTICS (2016)
Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2
Daniel J. Hodson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase
Thibault Courtheoux et al.
NATURE COMMUNICATIONS (2016)
Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study
Sandy Amorim et al.
LANCET HAEMATOLOGY (2016)
MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA/LYSA study
Christiane Copie-Bergman et al.
BLOOD (2015)
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenstroom macroglobulinaemia tumour cells
Kasyapa Chitta et al.
BRITISH JOURNAL OF HAEMATOLOGY (2015)
Front-line, dose-escalated immunochemotherapy is associated with a significant progression-free survival advantage in patients with double-hit lymphomas: a systematic review and meta-analysis
Christina Howlett et al.
BRITISH JOURNAL OF HAEMATOLOGY (2015)
Protein Lysine Acetylation by p300/CBP
Beverley M. Dancy et al.
CHEMICAL REVIEWS (2015)
Outcome of Patients With Non-Hodgkin Lymphomas With Concurrent MYC and BCL2 Rearrangements Treated With CODOX-M/IVAC With Rituximab Followed by Hematopoietic Stem Cell Transplantation
Haowei Sun et al.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2015)
Oral Debio 1143 (AT406), an Antagonist of Inhibitor of Apoptosis Proteins, Combined With Daunorubicin and Cytarabine in Patients With Poor-Risk Acute Myeloid Leukemia-Results of a Phase I Dose-Escalation Study
John F. DiPersio et al.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2015)
Everolimus in diffuse large B-cell lymphomas
Michele Merli et al.
FUTURE ONCOLOGY (2015)
PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones
Sandrine Sander et al.
IMMUNITY (2015)
Lenalidomide Combined With R-CHOP Overcomes Negative Prognostic Impact of Non-Germinal Center B-Cell Phenotype in Newly Diagnosed Diffuse Large B-Cell Lymphoma: A Phase II Study
Grzegorz S. Nowakowski et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1
L. Li et al.
LEUKEMIA (2015)
SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing
Yukiko Komeno et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
Rosalba Camicia et al.
MOLECULAR CANCER (2015)
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
Lu Jiang et al.
NATURE GENETICS (2015)
Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
Jiyuan Zhang et al.
NATURE MEDICINE (2015)
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development
Ana Ortega-Molina et al.
NATURE MEDICINE (2015)
CD70: An emerging target in cancer immunotherapy
J. Jacobs et al.
PHARMACOLOGY & THERAPEUTICS (2015)
AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
David Hong et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
B-Cell Receptor Signaling in Diffuse Large B-Cell lymphoma
Ryan M. Young et al.
SEMINARS IN HEMATOLOGY (2015)
Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma
Ling Li et al.
ONCOTARGET (2015)
Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma
Jiao Ma et al.
ONCOTARGET (2015)
Activating STAT6 mutations in follicular lymphoma
Mehmet Yildiz et al.
BLOOD (2015)
CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival
Maria Jose Moreno et al.
JOURNAL OF PATHOLOGY (2015)
TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations
Niklas Gebauer et al.
LEUKEMIA & LYMPHOMA (2015)
Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation
A. A. Sahasrabuddhe et al.
ONCOGENE (2015)
Therapeutic Targeting of the JAK/STAT Pathway
Saara Aittomaki et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)
Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma
Hongxiu Li et al.
BLOOD (2014)
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis
Tobias Berg et al.
BLOOD (2014)
Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients
Noel F. C. C. de Miranda et al.
BLOOD (2014)
Impact of induction regimen and stem cell transplantation on outcomes in double-hit lymphoma: a multicenter retrospective analysis
Adam M. Petrich et al.
BLOOD (2014)
Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma
Vicente Fresquet et al.
BLOOD (2014)
A multicentre phase II study of vorinostat in patients with relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma (vol 165, pg 768, 2014)
Michinori Ogura
BRITISH JOURNAL OF HAEMATOLOGY (2014)
Double hit lymphoma: the MD Anderson Cancer Center clinical experience
Yasuhiro Oki et al.
BRITISH JOURNAL OF HAEMATOLOGY (2014)
Combination of YM155, a Survivin Suppressant, with Bendamustine and Rituximab: A New Combination Therapy to Treat Relapsed/Refractory Diffuse Large B-cell Lymphoma
Naoki Kaneko et al.
CLINICAL CANCER RESEARCH (2014)
MYC translocation partner gene determines survival of patients with large B-cell lymphoma with MYC- or double-hit MYC/BCL2 translocations
Mette O. Pedersen et al.
EUROPEAN JOURNAL OF HAEMATOLOGY (2014)
Ibrutinib: a first in class covalent inhibitor of Bruton's tyrosine kinase
Matthew S. Davids et al.
FUTURE ONCOLOGY (2014)
Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma
Sietse M. Aukema et al.
HAEMATOLOGICA (2014)
B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies
Jose P. Vaque et al.
HAEMATOLOGICA (2014)
Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
Bing-Jia Chen et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2014)
Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies
Stephen M. Condon et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Sixteenth Biannual Report of the Cochrane Haematological Malignancies Group: Focus on Non-Hodgkin's Lymphoma
Michaela Rancea et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)
Lenalidomide plus R-CHOP21 in elderly patients with untreated diffuse large B-cell lymphoma: results of the REAL07 open-label, multicentre, phase 2 trial
Umberto Vitolo et al.
LANCET ONCOLOGY (2014)
Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma
Jagan R. Muppidi et al.
NATURE (2014)
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis
Arianna Sabo et al.
NATURE (2014)
ARID1B is a specific vulnerability in ARID1A-mutant cancers
Katherine C. Helming et al.
NATURE MEDICINE (2014)
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Peter E. Czabotar et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines
Richard J. Young et al.
PIGMENT CELL & MELANOMA RESEARCH (2014)
The Truncate Mutation of Notch2 Enhances Cell Proliferation through Activating the NF-κB Signal Pathway in the Diffuse Large B-Cell Lymphomas
Xinxia Zhang et al.
PLOS ONE (2014)
Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells
Elayne Hondares et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Diagnosis of 'double hit' diffuse large B-cell lymphoma and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma: when and how, FISH versus IHC
Steven H. Swerdlow
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2014)
Oct2 and Obf1 as facilitators of B:T cell collaboration during a humoral immune response
Lynn Corcoran et al.
FRONTIERS IN IMMUNOLOGY (2014)
The Novel Kinase Inhibitor PRT062070 (Cerdulatinib) Demonstrates Efficacy in Models of Autoimmunity and B-Cell Cancer
Greg Coffey et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)
Double-hit B-cell Lymphomas With BCL6 and MYC Translocations Are Aggressive, Frequently Extranodal Lymphomas Distinct From BCL2 Double-hit B-cell Lymphomas
Raju K. Pillai et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2013)
Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma
Paola Bonetti et al.
BLOOD (2013)
MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program
Shimin Hu et al.
BLOOD (2013)
Analysis of FOXO1 mutations in diffuse large B-cell lymphoma
Diane L. Trinh et al.
BLOOD (2013)
A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma
Hakim Bouamar et al.
BLOOD (2013)
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing
Ryan D. Morin et al.
BLOOD (2013)
Lenalidomide efficacy in activated B-cell-like subtype diffuse large B-cell lymphoma is dependent upon IRF4 and cereblon expression
Ling-Hua Zhang et al.
BRITISH JOURNAL OF HAEMATOLOGY (2013)
EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
Wendy Beguelin et al.
CANCER CELL (2013)
The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma
P. Bertrand et al.
GENES CHROMOSOMES & CANCER (2013)
MYC protein expression and genetic alterations have prognostic impact in patients with diffuse large B-cell lymphoma treated with immunochemotherapy
Alexandra Valera et al.
HAEMATOLOGICA (2013)
Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development
Qingjie Ding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Oral lenalidomide with rituximab in relapsed or refractory diffuse large cell, follicular and transformed lymphoma: a phase II clinical trial
M. Wang et al.
LEUKEMIA (2013)
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
Cigall Kadoch et al.
NATURE GENETICS (2013)
MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma
Carol Y. Ying et al.
NATURE IMMUNOLOGY (2013)
Targeting pathological B cell receptor signalling in lymphoid malignancies
Ryan M. Young et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Genetic heterogeneity of diffuse large B-cell lymphoma
Jenny Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
Matthias Pfeifer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL)
Olga Ritz et al.
ONCOTARGET (2013)
Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5
Huabo Wang et al.
ONCOTARGET (2013)
Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application
Muhammad Furqan et al.
BIOMARKER RESEARCH (2013)
Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies
Zijun Y. Xu-Monette et al.
BLOOD (2012)
Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study
Zijun Y. Xu-Monette et al.
BLOOD (2012)
Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells
Ze Tian et al.
BLOOD (2012)
FOXO1 is a tumor suppressor in classical Hodgkin lymphoma
Linka Xie et al.
BLOOD (2012)
TBL1XR1/TP63: a novel recurrent gene fusion in B-cell non-Hodgkin lymphoma
David W. Scott et al.
BLOOD (2012)
Inhibitors of B-Cell Receptor Signaling for Patients With B-Cell Malignancies
Michael Y. Choi et al.
CANCER JOURNAL (2012)
Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl
G. Monaco et al.
CELL DEATH AND DIFFERENTIATION (2012)
Immunohistochemical Double-Hit Score Is a Strong Predictor of Outcome in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone
Tina Marie Green et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Concurrent Expression of MYC and BCL2 in Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone
Nathalie A. Johnson et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1
Alex Karnowski et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
Joshua C. Black et al.
MOLECULAR CELL (2012)
BCL2 mutations in diffuse large B-cell lymphoma
J. M. Schuetz et al.
LEUKEMIA (2012)
Activation of mammalian target of rapamycin in diffuse large B-cell lymphoma: A clinicopathological study
Neerja Vajpayee et al.
LEUKEMIA RESEARCH (2012)
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
Roland Schmitz et al.
NATURE (2012)
Histone methylation: a dynamic mark in health, disease and inheritance
Eric L. Greer et al.
NATURE REVIEWS GENETICS (2012)
MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20)
Sang-Woo Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Biological Prognostic Markers in Diffuse Large B-Cell Lymphoma
Anamarija M. Perry et al.
CANCER CONTROL (2012)
Functional Analysis of In-frame Indel ARID1A Mutations Reveals New Regulatory Mechanisms of Its Tumor Suppressor Functions
Bin Guan et al.
NEOPLASIA (2012)
Sepantronium Bromide (YM155) Enhances Response of Human B-Cell Non-Hodgkin Lymphoma to Rituximab
Aya Kita et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
Damian B. Yap et al.
BLOOD (2011)
Combined Genetic Inactivation of β2-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B Cell Lymphoma
Madhavi Challa-Malladi et al.
CANCER CELL (2011)
Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Denis Drygin et al.
CANCER RESEARCH (2011)
Enzastaurin hydrochloride for lymphoma: reassessing the results of clinical trials in light of recent advances in the biology of B-cell malignancies
Loic Ysebaert et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2011)
Rational combinations of enzastaurin with novel targeted agents for patients with B-cell non-Hodgkin's lymphoma
Monica Civallero et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2011)
Mysterious link between iron overload and CDKN2A/2B
Shinya Toyokuni
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2011)
A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment
Qian Cai et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies
Jon C. Aster et al.
JOURNAL OF PATHOLOGY (2011)
The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells
Brian A. Zabel et al.
MOLECULAR CANCER (2011)
Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a phase 2 study
Stephen M. Ansell et al.
LANCET ONCOLOGY (2011)
GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia
X. Meng et al.
LEUKEMIA (2011)
Oncogenically active MYD88 mutations in human lymphoma
Vu N. Ngo et al.
NATURE (2011)
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
Laura Pasqualucci et al.
NATURE (2011)
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Ryan D. Morin et al.
NATURE (2011)
The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement
Jesse A. Green et al.
NATURE IMMUNOLOGY (2011)
Kruppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression
Geoffrey T. Hart et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Gamma-secretase inhibitor enhances the cytotoxic effect of bortezomib in multiple myeloma
Feng Chen et al.
CELLULAR ONCOLOGY (2011)
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
Irina Velichutina et al.
BLOOD (2010)
The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ-TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling
Mirza Suljagic et al.
BLOOD (2010)
Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
Derek Yecies et al.
BLOOD (2010)
CXCL12 Mediates Immunosuppression in the Lymphoma Microenvironment after Allogeneic Transplantation of Hematopoietic Cells
Christoph Duerr et al.
CANCER RESEARCH (2010)
Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma
Christopher J. Stasik et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2010)
Bcl-2 and Bax Interact via the BH1-3 Groove-BH3 Motif Interface and a Novel Interface Involving the BH4 Motif
Jingzhen Ding et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy
Leandro C. Cerchietti et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization
Dana M. Clausen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
R. Eric Davis et al.
NATURE (2010)
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
Ryan D. Morin et al.
NATURE GENETICS (2010)
Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
Kieron Dunleavy et al.
BLOOD (2009)
Targeted Disruption of the S1P2 Sphingosine 1-Phosphate Receptor Gene Leads to Diffuse Large B-Cell Lymphoma Formation
Giorgio Cattoretti et al.
CANCER RESEARCH (2009)
Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma
Suk-young Lee et al.
CANCER SCIENCE (2009)
Functional, Structural, and Genetic Evaluation of 20 CDKN2A Germ Line Mutations Identified in Melanoma-Prone Families or Patients
Caroline Kannengiesser et al.
HUMAN MUTATION (2009)
Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells
Uta Ferch et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
IFN Regulatory Factor 8 Regulates MDM2 in Germinal Center B Cells
Jeff X. Zhou et al.
JOURNAL OF IMMUNOLOGY (2009)
Transcription activity is required for p53-dependent tumor suppression
O. Gaidarenko et al.
ONCOGENE (2009)
Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: A novel germinal center marker
Antonio Martinez et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2008)
Enzastaurin
Yi-Bin Chen et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2008)
STAT6 activity is regulated by SOCS-1 and modulates BCL-XL expression in primary mediastinal B-Cell lymphoma
O. Ritz et al.
LEUKEMIA (2008)
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
Rupesh H. Amin et al.
NATURE IMMUNOLOGY (2008)
The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation
Shwu-Yuan Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma
Michael J. Robertson et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
Cyclin-dependent kinase inhibitor seliciclib shows in vitro activity in diffuse large B-cell lymphomas
Katia Lacrima et al.
LEUKEMIA & LYMPHOMA (2007)
The JAK-STAT signaling pathway: Input and output intergration
Peter J. Murray
JOURNAL OF IMMUNOLOGY (2007)
Establishment of a novel B-cell lymphoma cell line with suppressed growth by gamma-secretase inhibitors
Shuji Tohda et al.
LEUKEMIA RESEARCH (2006)
The regulation of INK4/ARF in cancer and aging
William Y. Kim et al.
CELL (2006)
Myc overexpression enhances apoptosis induced by small molecules
Hao Mo et al.
CELL CYCLE (2006)
Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
Karen W. L. Yee et al.
CLINICAL CANCER RESEARCH (2006)
FAS death domain deletions and cellular FADD-like interleukin 1β converting enzyme inhibitory protein (long) overexpression:: Alternative mechanisms for deregulating the extrinsic apoptotic pathway in diffuse large B-cell lymphoma subtypes
Hidenobu Takahashi et al.
CLINICAL CANCER RESEARCH (2006)
Bcl2's flexible loop domain regulates p53 binding and survival
Xingming Deng et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation
H Mo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
CH Lee et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
NFκB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes
F Feuerhake et al.
BLOOD (2005)
The p53 pathway: positive and negative feedback loops
SL Harris et al.
ONCOGENE (2005)
Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas
J Houldsworth et al.
BLOOD (2004)
The SWI/SNF complex - Chromatin and cancer
CWM Roberts et al.
NATURE REVIEWS CANCER (2004)
Stimulation of non-Hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity
RT Costello et al.
LEUKEMIA (2003)
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
T Saito et al.
IMMUNITY (2003)
Acetylation inactivates the transcriptional repressor BCL6
OR Bereshchenko et al.
NATURE GENETICS (2002)
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
T Berg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Toxicity and toxicokinetics of a phosphorothioate oligonucleotide against the c-myc oncogene in cynomolgus monkeys
MS Webb et al.
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT (2001)
Structural basis of IAP recognition by Smac/DIABLO
G Wu et al.
NATURE (2000)