4.7 Review

Cancer vaccines as promising immuno-therapeutics: platforms and current progress

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Review Biotechnology & Applied Microbiology

Identification of neoantigens for individualized therapeutic cancer vaccines

Franziska Lang et al.

Summary: This Review discusses the use of tumor-specific neoantigens in anticancer vaccines and introduces the mechanisms of neoantigen T cell recognition, as well as computational approaches to predict which neoantigens might confer proficient antitumor immunity in patients. Individualized treatment approaches are required to harness the full potential of the unique cancer mutations in each patient. Computational algorithms and machine-learning tools can be used to identify mutations, prioritize T cell-recognized antigens, and design personalized vaccines for each patient.

NATURE REVIEWS DRUG DISCOVERY (2022)

Review Biotechnology & Applied Microbiology

Revisiting the role of CD4+T cells in cancer immunotherapy-new insights into old paradigms

Rong En Tay et al.

Summary: Cancer immunotherapy has transformed cancer treatment, with immune checkpoint blockade therapy and adoptive cell therapy becoming standard care for many cancer types. Recent evidence suggests that CD4(+)T cells play a significant role in the anti-tumour immune response, highlighting their potential importance in cancer immunotherapies.

CANCER GENE THERAPY (2021)

Review Biotechnology & Applied Microbiology

Recent developments of RNA-based vaccines in cancer immunotherapy

Elnaz Faghfuri et al.

Summary: RNA vaccines show promising potential in cancer immunotherapy by stimulating adaptive immune responses to eliminate or reduce tumor burden. Improving RNA delivery technologies and chemical modifications can enhance the translation capacity and durability of these vaccines. Early clinical development of RNA vaccines has demonstrated safety and efficacy outcomes.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

Review Biochemistry & Molecular Biology

Self-amplifying RNA vaccines for infectious diseases

Kristie Bloom et al.

Summary: Vaccinology is moving towards synthetic RNA platforms, which offer rapid, scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. Self-amplifying RNAs have shown enhanced antigen expression at lower doses compared to conventional mRNA, potentially improving immunity and becoming important vaccine candidates.

GENE THERAPY (2021)

Review Oncology

Strategies in DNA vaccine for melanoma cancer

Tayebeh Rezaei et al.

Summary: Research has shown that malignant melanoma, though less prevalent than nonmelanoma skin cancers, is the major cause of skin cancer mortality. Hence, there is an urgent need to produce effective vaccines to control melanoma, with DNA vaccines being extensively investigated for melanoma therapy. Compared to conventional vaccination methods, DNA vaccines have advantages such as lack of severe side effects and high stability.

PIGMENT CELL & MELANOMA RESEARCH (2021)

Review Biochemistry & Molecular Biology

Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy

Maria Petrina et al.

Summary: GM-CSF acts as a pro-inflammatory cytokine and plays a crucial role in immune response against infections by activating key signaling pathways. It is also widely utilized in immunotherapy and as an adjuvant in vaccines for its mechanistic attributes.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

Article Oncology

Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer: a single-arm, open-label, repeat-dose clinical trial

Stephen A. Boorjian et al.

Summary: The study demonstrates the efficacy of intravesical nadofaragene firadenovec, a novel therapy using a replication-deficient recombinant adenovirus, in patients with BCG-unresponsive non-muscle-invasive bladder cancer, with a favorable benefit:risk ratio. The treatment led to a complete response in a significant proportion of patients with carcinoma in situ, and the adverse events were generally mild, with no treatment-related deaths reported.

LANCET ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

Zhuting Hu et al.

Summary: Personal neoantigen peptide vaccines induce long-lasting T cell responses in melanoma patients, broadening the spectrum of tumor-specific cytotoxicity and resulting in diverse T cell clones with cytotoxic gene signatures.

NATURE MEDICINE (2021)

Review Oncology

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

Eryn Blass et al.

Summary: Immunotherapy has revolutionized cancer treatment with the development of immune-checkpoint inhibitors and personalized neoantigen vaccines. These vaccines trigger specific T cell responses against individual patient's tumors, showing promising tumor-specific immunogenicity and antitumor activity.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Oncology

Myeloid and plasmacytoid dendritic cell combined vaccines loaded with heat-treated tumor cell lysates enhance antitumor activity in murine lung cancer

Huiguo Chen et al.

Summary: The study demonstrated that a combined vaccine of myeloid dendritic cells and plasmacytoid dendritic cells loaded with heat-treated cancer cell lysates can enhance T lymphocyte proliferation and increase CTL-mediated cytotoxicity against lung cancer cells, leading to significant inhibition of tumor growth.

ONCOLOGY LETTERS (2021)

Review Pharmacology & Pharmacy

Recombinant protein vaccines, a proven approach against coronavirus pandemics

Jeroen Pollet et al.

Summary: This article points out that recombinant protein vaccines may become a favorable option in the context of the COVID-19 pandemic, despite being overlooked in early development, they may offer an advantage or complement under the current circumstances.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Oncology

A Phase IIb Randomized Controlled Trial of the TLPLDC Vaccine as Adjuvant Therapy After Surgical Resection of Stage III/IV Melanoma: A Primary Analysis

Timothy J. Vreeland et al.

Summary: This study demonstrates that the TLPLDC vaccine is well-tolerated and improves disease-free survival in patients with resected stage III/IV melanoma, indicating potential benefits for preventing future recurrence in patients who do not recur early.

ANNALS OF SURGICAL ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Xiaoqi Mao et al.

Summary: CAFs, as a crucial component of TME, play significant roles in promoting tumor growth, invasion, and metastasis. The interaction between CAFs and tumor cells, as well as immune cells in TIME, is critical for tumor progression.

MOLECULAR CANCER (2021)

Review Biochemistry & Molecular Biology

mRNA vaccine for cancer immunotherapy

Lei Miao et al.

Summary: mRNA vaccines have emerged as a promising platform for cancer immunotherapy, showcasing high potency, safe administration, rapid development potentials, and cost-effective manufacturing. However, challenges such as stability, innate immunogenicity, and inefficient in vivo delivery restrict their applications. In addressing these challenges, structural modifications and formulation methods are being researched to enhance the anti-tumor immune response.

MOLECULAR CANCER (2021)

Article Virology

Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy

Valeria Morante et al.

Summary: The study validated the efficacy of the vaccine platform based on IDLVs for cancer immunotherapy in preclinical murine models, demonstrating the ability to eradicate and control tumor growth by delivering antigens such as OVA and TRP2.

VIRUSES-BASEL (2021)

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Clinical and Immunologic Responses to a B-Cell Epitope Vaccine in Patients with HER2/neu-Overexpressing Advanced Gastric Cancer-Results from Phase Ib Trial IMU.ACS.001

Ursula Wiedermann et al.

Summary: The study developed a therapeutic B-cell epitope vaccine (IMU-131/HER-Vaxx) for HER2/neu-overexpressing gastroesophageal adenocarcinoma patients. The vaccine was found to be safe and well-tolerated, inducing dose-dependent HER2-specific antibody and cellular responses, which correlated with clinical responses and prolonged progression-free survival in patients who received the highest dose of the vaccine. Further evaluation in a phase II trial combining chemotherapy with IMU-131 is ongoing.

CLINICAL CANCER RESEARCH (2021)

Review Biochemistry & Molecular Biology

mRNA therapeutics in cancer immunotherapy

Jan D. Beck et al.

Summary: Synthetic mRNA serves as a versatile template for protein synthesis and has a wide range of pharmaceutical applications, including cancer immunotherapy. Strategies such as stimulating pattern recognition receptors and nucleoside modification enhance the effectiveness and safety of mRNA vaccines.

MOLECULAR CANCER (2021)

Article Oncology

Multicenter, Open-Label, Phase I Study of DSP-7888 Dosing Emulsion in Patients with Advanced Malignancies

Alexander Spira et al.

Summary: The study demonstrated that DSP-7888 was well tolerated in patients with recurrent or advanced malignancies, with no dose-limiting toxicities observed. Furthermore, higher WT1-specific CTL induction activity was noted with intradermal administration, indicating the potential for improved immune response compared to subcutaneous administration.

TARGETED ONCOLOGY (2021)

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Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB-IVM1c melanoma

Josep Malvehy et al.

Summary: This study demonstrates that T-VEC induces systemic immune activity and modifies the tumor microenvironment, potentially enhancing the efficacy of combination immunotherapy with other agents.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Nanoscience & Nanotechnology

CpG-Based Nanovaccines for Cancer Immunotherapy

Wenqiang Chen et al.

Summary: Nanoparticles used as carriers and/or adjuvants in tumor vaccines have shown significant therapeutic effects in cancer treatment. CpG ODN, a commonly used immune stimulant, can activate humoral and cellular immunity through Toll-like receptor 9 for cancer prevention or treatment.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Medicine, General & Internal

Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil: test negative case-control study

Otavio Ranzani et al.

Summary: The study evaluates the effectiveness of the CoronaVac vaccine in the elderly population aged >= 70 years in Sao Paulo state, Brazil during widespread circulation of the gamma variant. The vaccine was found to significantly reduce the risk of symptomatic covid-19, hospital admissions, and deaths after completion of the two-dose regimen, but the effectiveness decreases with age among the elderly population.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Review Oncology

DC-Derived Exosomes for Cancer Immunotherapy

Yi Yao et al.

Summary: Dendritic cells (DCs)-based cancer vaccines have not been very successful due to tumor-mediated immunosuppression, leading to limited clinical efficacy. DC-derived exosomes (DCexos) are considered as a promising alternative to DC-based vaccines, as they are more resistant to tumor-mediated suppression and have shown better anti-tumor efficacy in pre-clinical models.

CANCERS (2021)

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Therapeutic cancer vaccines

Mansi Saxena et al.

Summary: Therapeutic cancer vaccines aim to induce tumor regression, eradicate minimal residual disease, establish lasting anti-tumor memory, and avoid non-specific or adverse reactions. However, challenges arise due to tumor-induced immunosuppression and immunoresistance, hindering the achievement of these goals.

NATURE REVIEWS CANCER (2021)

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Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion

Suchit Jhunjhunwala et al.

Summary: This review discusses the importance of antigen presentation in the success of immune checkpoint inhibition therapy and mechanisms by which tumors evade immune recognition. Tumors evade immune recognition by modulating antigen expression and altering antigen presentation.

NATURE REVIEWS CANCER (2021)

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The Changing Landscape of Therapeutic Cancer Vaccines-Novel Platforms and Neoantigen Identification

Jessica Jou et al.

Summary: Therapeutic cancer vaccines aim to create and enhance tumor-specific T-cell responses, but face challenges in achieving success. Researchers are exploring various strategies to overcome immunosuppressive mechanisms in the tumor microenvironment, improve vaccine delivery platforms, and utilize combination therapies.

CLINICAL CANCER RESEARCH (2021)

Review Immunology

Adenovirus Vectors: Excellent Tools for Vaccine Development

Jun Chang

Summary: Adenovirus, originally used for gene therapy, has seen increased utility as a vaccine vector in recent years with higher safety and immunogenicity. It is being tested for preventing infectious diseases and as cancer vaccines, with ongoing research to overcome limitations for improved vaccine development using adenovirus vectors.

IMMUNE NETWORK (2021)

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Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Filippo Veglia et al.

Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.

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A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity

Tim Beissert et al.

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Sergio Linares-Fernandez et al.

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Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma

Lihong Wang-Bishop et al.

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cGAS-STING, an important pathway in cancer immunotherapy

Minlin Jiang et al.

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Oncolytic viruses for cancer immunotherapy

Otto Hemminki et al.

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An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

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mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Gal Cafri et al.

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Yingying Wang et al.

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Dual-Antigen-Loaded Hepatitis B Virus Core Antigen Virus-like Particles Stimulate Efficient Immunotherapy Against Melanoma

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DC-Based Vaccines for Cancer Immunotherapy

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Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

Iuliia Efimova et al.

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Regulatory T cells in cancer immunosuppression - implications for anticancer therapy

Yosuke Togashi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Turning the corner on therapeutic cancer vaccines

Robert E. Hollingsworth et al.

NPJ VACCINES (2019)

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Cancer DNA vaccines: current preclinical and clinical developments and future perspectives

Alessandra Lopes et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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The clinical application of cancer immunotherapy based on naturally circulating dendritic cells

Kalijn F. Bol et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Studying interactions between dendritic cells and T cells in vivo

Aleksey Chudnovskiy et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

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Trial watch: dendritic cell vaccination for cancer immunotherapy

Jenny Sprooten et al.

ONCOIMMUNOLOGY (2019)

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EUROPEAN JOURNAL OF CANCER (2019)

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Neoantigen vaccine: an emerging tumor immunotherapy

Miao Peng et al.

MOLECULAR CANCER (2019)

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CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

Bagher Farhood et al.

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Actively personalized vaccination trial for newly diagnosed glioblastoma

Norbert Hilf et al.

NATURE (2019)

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FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

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MDSC; the Most Important Cell You Have Never Heard Of

R. J. Tesi

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Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics

Zong Sheng Guo et al.

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Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine

Victoria D. Turubanova et al.

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Tertiary lymphoid structures in the era of cancer immunotherapy

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Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators

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Antitumor Humoral and T Cell Responses by Mucin-1 Conjugates of Bacteriophage Q beta in Wild-type Mice

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Oncolytic Viruses as Antigen-Agnostic Cancer Vaccines

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First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

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Personalized vaccines for cancer immunotherapy

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Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification

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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

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Acetylation of Cytidine in mRNA Promotes Translation Efficiency

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Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes

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Oncolytic virus immunotherapy: future prospects for oncology

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CD4+ T cell help in cancer immunology and immunotherapy

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Danger signals: Chemotherapy enhancers?

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Myeloid-derived suppressor cellsa new therapeutic target to overcome resistance to cancer immunotherapy

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Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy

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Short poly(A) tails are a conserved feature of highly expressed genes

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Short poly(A) tails are a conserved feature of highly expressed genes

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Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity

John J. Suschak et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

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Codon-Optimized P1A-Encoding DNA Vaccine: Toward a Therapeutic Vaccination against P815 Mastocytoma

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The Importance of Immunization in Cancer Prevention, Treatment, and Survivorship

Elizabeth M. Ward et al.

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Clinical study of a survivin long peptide vaccine (SurVaxM) in patients with recurrent malignant glioma

Robert A. Fenstermaker et al.

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DNA vaccines to attack cancer: Strategies for improving immunogenicity and efficacy

Angeliki Tiptiri-Kourpeti et al.

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Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF

Tsuguhide Takeshima et al.

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Forced co-expression of IL-21 and IL-7 in whole-cell cancer vaccines promotes antitumor immunity

Yang-Zhuo Gu et al.

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Adjuvants for peptide-based cancer vaccines

Hiep Khong et al.

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Therapeutic cancer vaccines

Cornelis J. M. Melief et al.

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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

Stefani Spranger et al.

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Oncolytic viruses: a new class of immunotherapy drugs

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Mutation-Specific T Cells for Immunotherapy of Gliomas

Cornelis J. M. Melief

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An Ebola whole-virus vaccine is protective in nonhuman primates

Andrea Marzi et al.

SCIENCE (2015)

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Neoepitopes of Cancers: Looking Back, Looking Ahead

Pramod K. Srivastava

CANCER IMMUNOLOGY RESEARCH (2015)

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TGF-beta Activation and Function in Immunity

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Chimeric Rat/Human HER2 Efficiently Circumvents HER2 Tolerance in Cancer Patients

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Adenovirus-Based Vaccines for Fighting Infectious Diseases and Cancer: Progress in the Field

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Macrophages: Supportive cells for tissue repair and regeneration

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Therapeutic vaccines for cancer: an overview of clinical trials

Ignacio Melero et al.

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mRNA-based therapeutics - developing a new class of drugs

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From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation

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Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion

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