Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies

Article Oncology

Safety and preliminary immunogenicity of JNJ-64041809, a live-attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer

Charles G. Drake et al.

Summary: JNJ-809 demonstrated manageable safety and transiently induced peripheral cytokines. Limited antigen-specific immune responses were observed, but did not translate into objective clinical responses.

PROSTATE CANCER AND PROSTATIC DISEASES (2022)

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Article Multidisciplinary Sciences

Human gut bacteria produce TH17-modulating bile acid metabolites

Donggi Paik et al.

Summary: This study identifies bile acids produced by gut bacteria that inhibit the differentiation of T(H)17 cells, a key immune cell type involved in inflammatory disorders such as inflammatory bowel disease. The levels of these bile acids are reduced in patients with inflammatory bowel disease and are inversely correlated with the expression of T(H)17-cell-associated genes.

NATURE (2022)

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Article Biochemistry & Molecular Biology

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

John A. McCulloch et al.

Summary: An integrated analysis of microbiome and host cell transcriptional data in patients with melanoma treated with anti-PD-1 therapy reveals new associations between streptococcus species and immune-related adverse effects. The study also identifies consistent microbiome associations with clinical outcomes. The results show that baseline microbiota composition is optimally associated with clinical outcome one year after treatment initiation. Meta-analysis and bioinformatic analyses reveal that bacteria associated with favorable response are within the Actinobacteria phylum and Lachnospiraceae/Ruminococcaceae families of Firmicutes. Gram-negative bacteria, on the other hand, are associated with an inflammatory host intestinal gene signature and unfavorable outcome. Two different microbial signatures, enriched for Lachnospiraceae spp. and Streptococcaceae spp., are associated with favorable and unfavorable clinical response, respectively, along with distinct immune-related adverse effects. Supervised learning algorithms consistently predict treatment outcomes in all cohorts, despite heterogeneity between cohorts. The study provides valuable insights into the complex interaction between gut microbiome and response to cancer immunotherapy, paving the way for future research.

NATURE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

Nazli Dizman et al.

Summary: Adding a live bacterial product to an immunotherapy combination can enhance the clinical outcome in patients with metastatic renal cell carcinoma, showing longer progression-free survival and higher response rate.

NATURE MEDICINE (2022)

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Article Oncology

Comprehensive assessment of multiple tryptophan metabolites as potential biomarkers for immune checkpoint inhibitors in patients with non-small cell lung cancer

M. Karayama et al.

Summary: The study found significant differences in tryptophan metabolite levels between patients with non-small cell lung cancer and healthy volunteers, with 3-HAA levels correlating with treatment outcomes. Analysis of 3-HAA values can predict the efficacy of ICIs treatment.

CLINICAL & TRANSLATIONAL ONCOLOGY (2021)

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Review Oncology

Gut microbiota contributes towards immunomodulation against cancer: New frontiers in precision cancer therapeutics

Kentaro Inamura

Summary: The microbiota plays a significant role in oncogenesis and cancer therapy, and manipulating microbial networks may offer a promising strategy for treating and preventing cancer.

SEMINARS IN CANCER BIOLOGY (2021)

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Article Immunology

Clinical observation of the efficacy of PD-1/PD-L1 inhibitors in the treatment of patients with advanced solid tumors

Miao Wang et al.

Summary: This retrospective study evaluated the efficacy of PD-1/PD-L1 inhibitors in 90 patients with advanced solid tumors and explored the impact of clinical characteristics on treatment outcome. The results showed that the efficacy of PD-1/PD-L1 inhibitors was comparable to previous studies, and factors such as ECOG performance status, smoking status, liver metastasis, neutrophil-to-lymphocyte ratio, and lactate dehydrogenase level were independently correlated with progression-free survival and overall survival.

IMMUNITY INFLAMMATION AND DISEASE (2021)

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Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Microbiology

Gut microbial metabolites as multi-kingdom intermediates

Kimberly A. Krautkramer et al.

Summary: The gut microbiota influences host physiology through the production of various metabolites. By studying microbial metabolites, researchers have identified potential microbial targets relevant for host health, despite the challenges of understanding host-microbiota interactions.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Microbiology

The gut microbiota-brain axis in behaviour and brain disorders

Livia H. Morais et al.

Summary: This Review discusses the intricate and potentially important connections between the gut microbiota and the brain, involving bidirectional communication along the gut-brain axis. Emerging evidence suggests that disruptions in microbial communities may be implicated in neurological disorders, with animal models providing valuable insights into the pathways linking the gut and the brain which could have tangible impacts on human health.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Oncology

Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma

Lakshmi Nayak et al.

Summary: The study showed that pembrolizumab alone or in combination with bevacizumab had limited efficacy in the treatment of recurrent glioblastoma, failing to improve patient survival rates. Tumor immune biomarkers were not reliable predictors of treatment outcomes, while baseline dexamethasone use and certain tumor biomarkers may impact treatment efficacy.

CLINICAL CANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

Khiem C. Lam et al.

Summary: This study reveals how the microbiota influences the immune components of the TME to improve cancer therapy. Modulating the microbiota can trigger the IFN-I-NK cell-DC axis within tumors, enhancing the efficacy of immune checkpoint blockade (ICB).

CELL (2021)

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Article Cell Biology

Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

Daniel Erny et al.

Summary: Microglial features are strongly influenced by environmental cues, with gut bacteria-derived short-chain fatty acids (SCFAs) continuously modulating their maturation and function. Acetate, identified as a key microbiome-derived SCFA, drives microglia maturation and regulates metabolic state, playing a crucial role in their functions during health and perturbation.

CELL METABOLISM (2021)

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Article Gastroenterology & Hepatology

Cancer and the Microbiome-Influence of the Commensal Microbiota on Cancer, Immune Responses, and Immunotherapy

Vyara Matson et al.

Summary: The commensal microbiota plays a role in regulating various physiological processes, including affecting cancer immunotherapy either positively or negatively. Studies have shown that different microbes may have distinct impacts on immunotherapy efficacy, leading to clinical trials and microbiome-based therapeutic interventions.

GASTROENTEROLOGY (2021)

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Article Infectious Diseases

Periodic screening of donor faeces with a quarantine period to prevent transmission of multidrug-resistant organisms during faecal microbiota transplantation: a retrospective cohort study

Karuna E. W. Vendrik et al.

Summary: The study evaluated the effectiveness of the donor-screening protocol of the Netherlands Donor Faeces Bank, showing that healthy donors may become colonised with multidrug-resistant organisms during donation activities, but the screening protocol was effective in reducing the spread of such organisms.

LANCET INFECTIOUS DISEASES (2021)

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Article Immunology

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor

Yuying Liu et al.

Summary: IL-2 acts as an environmental cue to induce CD8(+) T cell exhaustion within tumor microenvironments by activating STAT5, inducing tryptophan hydroxylase 1, and subsequently causing T cell dysfunction.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

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Article Immunology

Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

Abigail E. Overacre-Delgoffe et al.

Summary: The study showed that introducing specific intestinal bacteria can enhance anti-colorectal cancer immunity and promote tumor control. This anti-tumor immunity is dependent on CD4(+) T cells, B cells, and NK cells.

IMMUNITY (2021)

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Article Pharmacology & Pharmacy

Anacardic 6-pentadecyl salicylic acid induces apoptosis in breast cancer tumor cells, immunostimulation in the host and decreases blood toxic effects of taxol in an animal model

J. N. Rashida Gnanaprakasam et al.

Summary: 6-pentadecyl salicylic acid (6SA) shows effective antineoplastic activity against breast cancer cells by inducing caspase-8-mediated apoptosis, reducing tumor volume without decreasing tumor-infiltrated lymphocytes. Additionally, 6SA reduces lung metastasis, increases immune cell proportion in blood, lymph nodes, and bone marrow, including tumor-infiltrating NK cells and cytotoxic T lymphocytes. Treatment with 6SA also improves the antitumoral immunological microenvironment and overall survival of animals, without causing myelosuppression or immunosuppression like Taxol.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Metabolic modulation of tumours with engineered bacteria for immunotherapy

Fernando P. Canale et al.

Summary: Engineered bacteria were developed to convert ammonia to l-arginine in tumors, increasing intratumoral l-arginine concentrations, T cell infiltration, and synergistic effects with PD-L1 blocking antibodies in tumor clearance. These results indicate that microbial therapies can enhance immunotherapy efficacy by modulating the tumor microenvironment.

NATURE (2021)

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Editorial Material Immunology

Microbiota shape tumor immunity

Zoltan Fehervari

NATURE IMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

Leveraging diet to engineer the gut microbiome

Mathis Wolter et al.

Summary: Autoimmune diseases share patterns of gut microbiome perturbation and immune dysregulation linked to intestinal barrier dysfunction. Dietary tools for precise engineering of the gut microbiome have the potential to modulate host-microbiome interaction in the treatment of autoimmune diseases.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Diwakar Davar et al.

Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection

Eric R. Littmann et al.

Summary: The inflammatory status of the recipient plays a crucial role in engraftment and efficacy of microbiota transplantation in treating C. difficile infection, with CD4(+) Foxp3(+) T-regulatory cells being crucial for resolving the infection.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

Yao He et al.

Summary: Recent studies suggest that gut microbial metabolite butyrate can enhance the efficacy of oxaliplatin by modulation of CD8(+) T cell immunity through an ID2-dependent mechanism. This finding has important implications for cancer therapy in patients responding to oxaliplatin.

CELL METABOLISM (2021)

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Article Multidisciplinary Sciences

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

Keman Cheng et al.

Summary: The study demonstrates a versatile OMV-based vaccine platform that can elicit a specific anti-tumor immune response by specifically presenting tumor antigens on the OMV surface. By employing a Plug-and-Display system, the engineered OMVs can simultaneously display multiple, distinct tumor antigens to promote a synergistic anti-tumor immune response.

NATURE COMMUNICATIONS (2021)

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Review Microbiology

Bacterial Outer Membrane Vesicles: From Discovery to Applications

Mariana G. Sartorio et al.

Summary: Production of extracellular vesicles in bacteria, particularly outer membrane vesicles (OMVs) in gram-negative bacteria, is a well-documented but poorly understood process. Besides their roles in pathogenesis, cell-to-cell communication, and stress responses, OMVs also play important roles in immunomodulation and balancing the gut microbiota. The review discusses the various roles of OMVs and the current understanding of their biogenesis, as well as the expanding biotechnological applications of OMVs.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021 (2021)

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Article Immunology

Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex

Bat-Erdene Jugder et al.

Summary: Microbe-derived acetate activates the IMD pathway in a subset of enteroendocrine cells in the anterior midgut of Drosophila. This pathway co-regulates expression of antimicrobial and enteroendocrine peptides, including a repressor of intestinal lipid synthesis. Acetate appears to enhance IMD signaling through the monocarboxylic acid transporter Tarag and histone deacetylation in enteroendocrine cells. Tip60-dependent chromatin remodeling modulates host metabolism and intestinal innate immunity via a steroid hormone axis conserved in mammals.

IMMUNITY (2021)

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Article Biochemistry & Molecular Biology

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Miles C. Andrews et al.

Summary: The study showed that tumor-associated immune and genomic biomarkers of response to combined immune checkpoint blockade (CICB) in melanoma patients were similar to those of monotherapy, while toxicity from CICB was associated with a more diverse peripheral T-cell repertoire. Additionally, analysis of gut microbiota revealed a higher abundance of Bacteroides intestinalis in patients experiencing toxicity, along with an upregulation of the inflammatory factor IL-1 beta in colitis samples.

NATURE MEDICINE (2021)

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Review Microbiology

Host specificity of the gut microbiome

Elizabeth K. Mallott et al.

Summary: In this Review, the authors summarize the prevalence of phylosymbiosis across the animal kingdom and explore the microbial community assembly processes and related host traits that contribute to phylosymbiosis. Phylosymbiosis is less common in taxonomically richer microbiomes, except in mammals, potentially due to unique mammalian traits influencing the microbiota. Understanding the principles of host-microorganism interactions requires a robust comprehension of eco-evolutionary processes that shape microbiota.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Medicine, General & Internal

Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma

Paul Nathan et al.

Summary: The randomized trial of tebentafusp for metastatic uveal melanoma showed a higher 1-year overall survival rate among patients who received tebentafusp compared to those who received the investigator's choice of therapy, indicating superior efficacy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

How microbiota improve immunotherapy

Eduard Ansaldo et al.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy

Matthew E. Griffin et al.

Summary: This study found that members of the Enterococcus bacterial genus can improve checkpoint inhibitor immunotherapy in mouse tumor models through the expression and secretion of immune-active murpeptides. Additionally, expression of this enzyme in nonprotective bacteria can also enhance immunotherapy response, requiring another bacterial sensor for its activity.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

Maik Luu et al.

Summary: Short-chain fatty acids pentanoate and butyrate can enhance the anti-tumor activity of immune cells through metabolic and epigenetic reprogramming, making them potential therapeutic agents in cancer immunotherapy.

NATURE COMMUNICATIONS (2021)

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Article Oncology

Overcoming PD-1 Blockade Resistance with CpG-A Toll-Like Receptor 9 Agonist Vidutolimod in Patients with Metastatic Melanoma

Antoni Ribas et al.

Summary: In patients with advanced melanoma, combining intratumoral TLR9 agonist vidutolimod with pembrolizumab showed promising clinical activity and manageable safety profile, indicating potential to overcome resistance to PD-1 blockade through IFN response induction.

CANCER DISCOVERY (2021)

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Review Immunology

Enhancing Checkpoint Inhibitor Therapy in Solid Tissue Cancers: The Role of Diet, the Microbiome & Microbiome-Derived Metabolites

Agnieszka Beata Malczewski et al.

Summary: The role of host immunity in regulating anti-tumour responses during checkpoint inhibitor therapy, particularly the impact of the microbiome and its metabolites, in enhancing responses to current CIT in solid tissue cancers, is the focus of this review. Various therapeutic approaches are being explored to modulate immunity and improve responses to current CIT, with a particular interest in monitoring bacterial metabolic products as a potential means of identifying patients at risk of poor immunotherapy responses.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

High-salt diet mediates interplay between NK cells and gut microbiota to induce potent tumor immunity

Zaigham Abbas Rizvi et al.

Summary: High-salt diet modulates tumor immunity by regulating gut microbiome, inducing NK cell-dependent immune response that inhibits tumor growth.

SCIENCE ADVANCES (2021)

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Article Oncology

Cumulative Antibiotic Use Significantly Decreases Efficacy of Checkpoint Inhibitors in Patients with Advanced Cancer

Nadina Tinsley et al.

ONCOLOGIST (2020)

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Article Oncology

Outcomes associated with immune-related adverse events in metastatic non-small cell lung cancer treated with nivolumab: a pooled exploratory analysis from a global cohort

Abdul Rafeh Naqash et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Review Oncology

The effect of antibiotics on clinical outcomes in immune-checkpoint blockade: a systematic review and meta-analysis of observational studies

Brooke E. Wilson et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Review Oncology

Targeted cancer immunotherapy with genetically engineered oncolytic Salmonella typhimurium

Yanxia Guo et al.

CANCER LETTERS (2020)

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Article Immunology

Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling

Yaoyao Shi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Microbiology

Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth

Elena Zagato et al.

NATURE MICROBIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

Laura Schaupp et al.

CELL (2020)

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Review Cell Biology

Immune checkpoint signaling and cancer immunotherapy

Xing He et al.

CELL RESEARCH (2020)

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Review Cell Biology

Interaction between microbiota and immunity in health and disease

Danping Zheng et al.

CELL RESEARCH (2020)

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Article Urology & Nephrology

Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients

Lisa Derosa et al.

EUROPEAN UROLOGY (2020)

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Article Immunology

Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity

Thomas M. Fenton et al.

IMMUNITY (2020)

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Article Multidisciplinary Sciences

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Daniel S. Leventhal et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

Relationship between intestinal flora structure and metabolite analysis and immunotherapy efficacy in Chinese NSCLC patients

Peng Song et al.

THORACIC CANCER (2020)

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Article Microbiology

Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway

Xinjian Xu et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Oncology

Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non -randomised, open -label, phase 2 trial

Sarah B. Goldberg et al.

LANCET ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

Clarissa Campbell et al.

NATURE (2020)

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Article Immunology

NK cells mediate clearance of CD8(+) T cell-resistant tumors in response to STING agonists

Christopher J. Nicolai et al.

SCIENCE IMMUNOLOGY (2020)

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Meeting Abstract Oncology

Oral delivery of a single microbial strain, EDP1503, induces anti-tumor responses via gut-mediated activation of both innate and adaptive immunity

D. McHale et al.

ANNALS OF ONCOLOGY (2020)

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Article Medicine, Research & Experimental

Commensal bacteria stimulate antitumor responses via T cell cross-reactivity

Catherine A. Bessell et al.

JCI INSIGHT (2020)

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Article Chemistry, Multidisciplinary

Bacterial outer membrane vesicles as a platform for biomedical applications: An update

Min Li et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Medicine, General & Internal

Association of Short-Chain Fatty Acids in the Gut Microbiome With Clinical Response to Treatment With Nivolumab or Pembrolizumab in Patients With Solid Cancer Tumors

Motoo Nomura et al.

JAMA NETWORK OPEN (2020)

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Article Chemistry, Multidisciplinary

Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

Shuang Qing et al.

ADVANCED MATERIALS (2020)

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Editorial Material Oncology

A Microbiota-Derived Metabolite Augments Cancer Immunotherapy Responses in Mice

Emma Allen-Vercoe et al.

CANCER CELL (2020)

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Article Immunology

The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin

Jeremy Di Domizio et al.

NATURE IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

Lukas F. Mager et al.

SCIENCE (2020)

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Article Gastroenterology & Hepatology

Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling

Xinhua Chen et al.

GASTROENTEROLOGY (2020)

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Article Multidisciplinary Sciences

Gut microorganisms act together to exacerbate inflammation in spinal cords

Eiji Miyauchi et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade

Shan Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Oncology

The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non-Small Cell Lung Cancer

Taiki Hakozaki et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Lydia Kalafati et al.

CELL (2020)

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Article Endocrinology & Metabolism

Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction

Tingting Wang et al.

NATURE METABOLISM (2020)

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Article Oncology

Effect of Antibiotic Use on Outcomes with Systemic Therapies in Metastatic Renal Cell Carcinoma

Aly-Khan A. Lalani et al.

EUROPEAN UROLOGY ONCOLOGY (2020)

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Review Oncology

Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy

Romain Daillere et al.

ONCOIMMUNOLOGY (2020)

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Article Veterinary Sciences

Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4/NF-κB signalling pathway

Yicong Chang et al.

VETERINARY RESEARCH (2020)

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Article Multidisciplinary Sciences

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Aurelie Fluckiger et al.

SCIENCE (2020)

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Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Oncology

Modulating the microbiome to improve therapeutic response in cancer

Jennifer L. McQuade et al.

LANCET ONCOLOGY (2019)

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Article Multidisciplinary Sciences

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Takeshi Tanoue et al.

NATURE (2019)

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Article Multidisciplinary Sciences

The flagellin of candidate live biotherapeutic Enterococcus gallinarum MRx0518 is a potent immunostimulant

Delphine L. Laute-Caly et al.

SCIENTIFIC REPORTS (2019)

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Article Multidisciplinary Sciences

Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a

S. H. Pennington et al.

SCIENCE ADVANCES (2019)

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Review Oncology

Genetically engineered Salmonella Typhimurium: Recent advances in cancer therapy

Kang Liang et al.

CANCER LETTERS (2019)

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Article Oncology

The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC

Yueping Jin et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

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Article Oncology

Antibiotics are associated with attenuated efficacy of anti-PD-1/PD-L1 therapies in Chinese patients with advanced non-small cell lung cancer

Sha Zhao et al.

LUNG CANCER (2019)

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Article Gastroenterology & Hepatology

Roseburia intestinalis inhibits oncostatin M and maintains tight junction integrity in a murine model of acute experimental colitis

Bei Tan et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2019)

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Article Oncology

Real-world efficacy and safety of nivolumab in previously-treated metastatic renal cell carcinoma, and association between immune-related adverse events and survival: the Italian expanded access program

Elena Verzoni et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Oncology

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Stefanie K. Wculek et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Oncology

A Metabolism Toolbox for CAR T Therapy

Xuequn Xu et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Immunology

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

Annabel Bachem et al.

IMMUNITY (2019)

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Review Immunology

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

Selena Vigano et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with updates hepatocellular carcinoma

Yi Zheng et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Editorial Material Biotechnology & Applied Microbiology

Immuno-oncology drug development goes global

Jia Xin Yu et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Oncology

Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer

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JAMA ONCOLOGY (2019)

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Article Medicine, General & Internal

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

Zachariah DeFilipp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Multidisciplinary Sciences

Metabolomic adaptations and correlates of survival to immune checkpoint blockade

Haoxin Li et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

Kathrin Renner et al.

CELL REPORTS (2019)

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Correction Oncology

Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab (vol 28, pg 1368, 2017)

N. Chaput et al.

ANNALS OF ONCOLOGY (2019)

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Review Immunology

Mining the microbiota for microbial and metabolite-based immunotherapies

Ashwin N. Skelly et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Oncology

Molecular Mechanisms and Countermeasures of Immunotherapy Resistance in Malignant Tumor

Xiaoyue Jiang et al.

JOURNAL OF CANCER (2019)

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Article Multidisciplinary Sciences

Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade

Feng Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Multidisciplinary Sciences

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

V. Gopalakrishnan et al.

SCIENCE (2018)

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Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

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Review Biotechnology & Applied Microbiology

Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?

Barbara Maciejewska et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Guanine and inosine nucleotides/nucleosides suppress murine T cell activation

Yuria Shinohara et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

Jan P. Boettcher et al.

CELL (2018)

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Editorial Material Urology & Nephrology

Re: Gut Microbiome Influences Efficacy of PD-1-based Immunotherapy Against Epithelial Tumors

Matteo Santoni et al.

EUROPEAN UROLOGY (2018)

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Article Immunology

Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism

Aurelien Trompette et al.

IMMUNITY (2018)

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Article Biochemistry & Molecular Biology

A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments

Kevin C. Barry et al.

NATURE MEDICINE (2018)

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Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells

Chi Ma et al.

SCIENCE (2018)

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The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients

Vyara Matson et al.

SCIENCE (2018)

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Article Oncology

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer

Friedrich H. Schmitz-Winnenthal et al.

ONCOIMMUNOLOGY (2018)

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Article Cell Biology

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

Yanhai Feng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Review Oncology

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

Spencer C. Wei et al.

CANCER DISCOVERY (2018)

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Article Multidisciplinary Sciences

Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate

Maik Luu et al.

SCIENTIFIC REPORTS (2018)

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Article Oncology

STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers

Dayson Moreira et al.

CLINICAL CANCER RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

Yinghong Wang et al.

NATURE MEDICINE (2018)

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Letter Gastroenterology & Hepatology

Nod-Like Receptor Pyrin-Containing Protein 6 (NLRP6) Is Up-regulated in Ileal Crohn's Disease and Differentially Expressed in Goblet Cells

Nicole Ranson et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

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Review Oncology

Tumour-targeting bacteria engineered to fight cancer

Shibin Zhou et al.

NATURE REVIEWS CANCER (2018)

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Article Medicine, Research & Experimental

Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12

Mireia Uribe-Herranz et al.

JCI INSIGHT (2018)

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Article Immunology

Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors

Baokun He et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Review Biochemistry & Molecular Biology

Neutrophil extracellular traps: protagonists of cancer progression?

L. Erpenbeck et al.

ONCOGENE (2017)

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Article Oncology

Preclinical efficacy and safety of the Ty21a vaccine strain for intravesical immunotherapy of non-muscle-invasive bladder cancer

Sonia Domingos-Pereira et al.

ONCOIMMUNOLOGY (2017)

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Article Oncology

Reactivity toward Bifidobacterium longum and Enterococcus hirae demonstrate robust CD8+ T cell response and better prognosis in HBV-related hepatocellular carcinoma

Yihui Rong et al.

EXPERIMENTAL CELL RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Lactobacillus plantarum Enhanced IL-22 Production in Natural Killer (NK) Cells That Protect the Integrity of Intestinal Epithelial Cell Barrier Damaged by Enterotoxigenic Escherichia coli

Yueqin Qiu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Vinod P. Balachandran et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Bacterial outer membrane vesicles suppress tumor by interferon-γ- mediated antitumor response

Oh Youn Kim et al.

NATURE COMMUNICATIONS (2017)

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Article Oncology

The impact of antibiotic usage on the efficacy of chemoimmunotherapy is contingent on the source of tumor-reactive T cells

Michal P. Kuczma et al.

ONCOTARGET (2017)

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Article Oncology

Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients

Arthur E. Frankel et al.

NEOPLASIA (2017)

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Article Critical Care Medicine

Microbes Are Associated with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis

Yong Huang et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

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Article Oncology

Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab

N. Chaput et al.

ANNALS OF ONCOLOGY (2017)

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Review Immunology

Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology

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IMMUNOLOGICAL REVIEWS (2016)

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Review Biochemistry & Molecular Biology

Microbiome and Anticancer Immunosurveillance

Laurence Zitvogel et al.

CELL (2016)

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Article Biochemistry & Molecular Biology

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Roger Geiger et al.

CELL (2016)

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Article Microbiology

Gut Microbial Metabolites Fuel Host Antibody Responses

Myunghoo Kim et al.

CELL HOST & MICROBE (2016)

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Article Immunology

Memory CD8+ T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

Maria L. Balmer et al.

IMMUNITY (2016)

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Article Biochemistry & Molecular Biology

Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity

Andrew Hollands et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Chemistry, Medicinal

Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING)

Thierry Lioux et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Article Nutrition & Dietetics

Randomized Clinical Trial: Impact of Oral Administration of Saccharomyces boulardii on Gene Expression of Intestinal Cytokines in Patients Undergoing Colon Resection

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JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2016)

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Article Multidisciplinary Sciences

Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

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NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

A novel strain of Bacteroides fragilis enhances phagocytosis and polarises M1 macrophages

Huimin Deng et al.

SCIENTIFIC REPORTS (2016)

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Article Pharmacology & Pharmacy

An Aryl Hydrocarbon Receptor-Mediated Amplification Loop That Enforces Cell Migration in ER-/PR-/Her2- Human Breast Cancer Cells

Olga Novikov et al.

MOLECULAR PHARMACOLOGY (2016)

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Article Immunology

The anacardic 6-pentadecyl salicylic acid induces macrophage activation via the phosphorylation of ERK1/2, JNK, P38 kinases and NF-κB

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INTERNATIONAL IMMUNOPHARMACOLOGY (2015)

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Article Agriculture, Multidisciplinary

Exopolysaccharides Produced by Leuconostoc mesenteroides Strain NTM048 as an Immunostimulant To Enhance the Mucosal Barrier and Influence the Systemic Immune Response

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

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Review Biochemistry & Molecular Biology

Cancer's Fuel Choice: New Flavors for a Picky Eater

Gina M. DeNicola et al.

MOLECULAR CELL (2015)

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Article Multidisciplinary Sciences

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

Ayelet Sivan et al.

SCIENCE (2015)

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Article Multidisciplinary Sciences

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Marie Vetizou et al.

SCIENCE (2015)

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Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Colin Hill et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

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Article Multidisciplinary Sciences

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

Noriho Iida et al.

SCIENCE (2013)

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Article Multidisciplinary Sciences

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

Sophie Viaud et al.

SCIENCE (2013)

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Review Pharmacology & Pharmacy

Emerging Roles of Anacardic Acid and Its Derivatives: A Pharmacological Overview

Mahadevappa Hemshekhar et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2012)

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Article Microbiology

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

Yue Shen et al.

CELL HOST & MICROBE (2012)

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Article Cell Biology

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

Dallas R. Donohoe et al.

CELL METABOLISM (2011)

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Article Biochemistry & Molecular Biology

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

Thomas B. Clarke et al.

NATURE MEDICINE (2010)

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Article Medicine, Research & Experimental

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling

Chrystal M. Paulos et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Article Biochemistry & Molecular Biology

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system

SK Mazmanian et al.

CELL (2005)

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Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies

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