期刊
JOURNAL OF HEMATOLOGY & ONCOLOGY
卷 15, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13045-022-01261-z
关键词
RNA sensor; Tumor microenvironment; Immunotherapy
资金
- Natural Science Foundation of Shanghai [22ZR1450700]
- National Natural Science Foundation of China [81971340, 81502230]
RNA sensors play an important role in activating anti-tumor immune responses in the tumor microenvironment (TME) and could be potential targets for cancer immunotherapy, synergizing with other immunotherapies.
RNA sensors detect foreign and endogenous RNAs to protect the host by initiating innate and adaptive immune response. In tumor microenvironment (TME), activation of RNA sensors induces tumor-inhibitory cytotoxic T lymphocyte responses and inhibits the activity of immunosuppressive cells though stimulating type I IFN signaling pathway. These characteristics allow RNA sensors to be prospective targets in tumor immunotherapy. Therefore, a comprehensive understanding of the roles of RNA sensors in TME could provide new insight into the antitumor immunotherapy. Moreover, RNA sensors could be prominent triggering targets to synergize with immunotherapies. In this review, we highlight the diverse mechanisms of RNA sensors in cancer immunity and their emerging contributions in cancer immunotherapy, including monotherapy with RNA sensor agonists, as well as combination with chemotherapy, radiotherapy, immune checkpoint blockade or cancer vaccine.
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