期刊
JOURNAL OF HAZARDOUS MATERIALS
卷 426, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jhazmat.2021.128028
关键词
Antibiotic-resistant bacteria; Antibiotic resistance genes; Hospital; Urine; Electrochemical disinfection
资金
- Junta de Comunidades de Castilla-La Mancha (JCCM)
- European Union (European Regional Development Fund)
- Ministry of Science and Innovation [SBPLY/17/180501/000396, PID2019-110904RB-I00]
- European Union [EQC2018-004469-P]
- Spanish Ministry of Science, Innovation, and Universities [PEJ2018-002784-A]
The study demonstrated the effectiveness of using MIKROZON (R) cell for disinfecting complex urine, achieving total disinfection and reducing the concentration of antibiotic resistance genes. This electrochemical technology could be a promising tool to reduce the risk of antibiotic resistance spread.
In this work, data obtained from the University Hospital Complex of Albacete (Spain) were selected as a case study to carry out the disinfection experiments. To do this, different configurations of electrochemical reactors were tested for the disinfection of complex urines. Results showed that 4-6 logs bacterial removal were achieved for every bacterium tested when working with a microfluidic flow-through reactor after 180 min (0.423 Ah dm-3). The MIKROZON (R) cell reached a total disinfection after 60 min (1.212 Ah dm-3), causing severe damages induced in the cell walls observed in SEM images. The concentration profiles of the electrogenerated disinfectants in solution could explain the differences observed. Additionally, a mean decrease in the ARGs concentration ranked as follows: blaKPC (4.18-logs) > blaTEM (3.96-logs) > ermB (3.23-logs) using the MIKROZON (R) cell. This electro-ozonizer could be considered as a suitable alternative to reduce the risk of antibiotic resistance spread. Hence, this study provides an insight into different electrochemical reactors for the disinfection of complex hospital urine matrices and contributes to reduce the spread of antibiotic resistance through the elimination of ARGs. A topic of great importance nowadays that needs to be further studied.
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