Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions

Coat protein complex II (COPII)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum (ER) to different destinations. cTAGE5/MEA6 is essential for the development and function of different organs. It regulates the assembly of COPII carrier and cargo trafficking through direct or indirect interaction with COPII components. cTAGE5/MEA6 mainly coordinates with another scaffold protein, TANGO1, to play essential roles in the trafficking and secretion of both large and small cargoes in multiple organs. In this viewpoint, we would like to discuss the molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions. Copyright (C) 2022, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

Automated summary

COPII-coated vesicles are responsible for transporting cargoes from the endoplasmic reticulum to different destinations. cTAGE5/MEA6 plays essential roles in the development and function of various organs by regulating COPII carrier assembly and cargo trafficking through interaction with COPII components, mainly in coordination with scaffold protein TANGO1.