4.6 Article

Comparative Effectiveness and Safety of Intrauterine Contraception and Tubal Ligation

期刊

JOURNAL OF GENERAL INTERNAL MEDICINE
卷 37, 期 16, 页码 4168-4175

出版社

SPRINGER
DOI: 10.1007/s11606-022-07433-4

关键词

comparative effectiveness; intrauterine contraception; tubal ligation; permanent contraception; female sterilization; Medicaid; low income; disparities; reproductive justice

资金

  1. Patient-Centered Outcomes Research Institute [1609-36359]

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This study compares the effectiveness and safety of intrauterine contraceptives (IUC) to laparoscopic tubal ligation for Medicaid clients. The results indicate that IUC is at least as effective as tubal ligation in preventing pregnancy at 1-year post-procedure, with lower rates of infection and pelvic pain 6 to 12 months post-procedure.
Background Tubal ligation remains common in the USA, especially among low-income patients. Objective To compare the effectiveness and safety of intrauterine contraceptives (IUC) to laparoscopic tubal ligation for Medicaid clients. Design We partnered with patient and clinician stakeholders to conduct a retrospective cohort study using California Medicaid claims for patients who had an IUC placed or laparoscopic tubal ligation performed in 2008-2014, excluding procedures performed within 42 days of a birth. We applied log-linear (Poisson) event-history regression models for clustered person-period data to adjust for sociodemographic variables and pre-procedure health status when examining associations between these contraceptive procedures and claims related to contraceptive failure, complications, and pain in the first year post-procedure. Key Results We identified 35,705 patients who had a levonorgestrel IUC placed, 23,628 patients who had a copper IUC placed, and 23,965 patients who underwent laparoscopic tubal ligation. In unadjusted analyses, rates of pregnancy within 1 year were similar following levonorgestrel IUC (2.40%) or copper IUC placement (2.99%) or tubal ligation (2.64%). In adjusted analyses, compared to tubal ligation, pregnancy was less common following placement of a levonorgestrel IUC (adj IRR 0.72, 95% CI 0.64-0.82) and similar with placement of a copper IUC (adj IRR 0.92, 95% CI 0.82-1.05). Procedural complications such as infection (0.35% vs. 2.91%) were significantly less common with IUC placement than tubal ligation. Claims for pelvic and abdominal pain decreased in frequency with time since all procedures; 6 to 12 months post-procedure, pelvic pain claims were less common after levonorgestrel IUC (adj IRR 0.69, 95% CI 0.65-0.73) or copper IUC placement (adj IRR 0.70, 95% CI 0.66-0.75) than tubal ligation. Conclusions IUC appears at least as effective as laparoscopic tubal ligation at 1-year post-procedure with lower rates of infection and pelvic pain 6 to 12 months post-procedure.

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