期刊
JOURNAL OF FOOD BIOCHEMISTRY
卷 46, 期 7, 页码 -出版社
WILEY
DOI: 10.1111/jfbc.14149
关键词
AMPK; HFD; lipids; liver; NAFLD; NF-kappa B; Nrf2; SREBP1c; Zingerone
资金
- deanship of scientific research at KKU
This study found that Zingerone has the potential to protect against the development of non-alcoholic fatty liver disease caused by a high-fat diet. The protection is mediated by modulating AMP-activated protein kinase (AMPK). Zingerone treatment can attenuate weight gain, preserve liver structure, and regulate various biochemical markers associated with oxidative stress, inflammation, and apoptosis. This protective effect is dependent on the activation of AMPK.
This study was conducted to test the protective potential of Zingerone against a high-fat diet (HFD)-mediated non-alcoholic fatty liver disease (NAFLD) development in rats and examined in this protection is mediated modulating AMP-activated protein kinase (AMPK). Animals were segregated based on their diet and treatment into four groups (n = 6 each): (a) fed standard diet (STD), (b) treated with Zingerone (100 mg/kg), (c) fed HFD, (d) HFD + Zingerone (100 mg/kg), and (e) HFD + Zingerone (100 mg/kg) + compound c (CC) (an AMPK inhibitor) (0.2 mg/kg). The treatment with Zingerone attenuated the gain in final body weights, preserved liver structure, and downregulated the transcription of Bax and cleaved caspase-3. In the HFD and STD--fed rats, Zingerone reduced levels of fasting glucose and insulin and circulatory levels of cholesterol (CHOL) and triglycerides (TGs). Concomitantly, Zingerone enhanced glutathione (GSH) and superoxide dismutase (SOD) levels, depleted levels of malondialdehyde (MDA), and enhanced the nuclear levels of the nuclear factor erythroid 2-related factor 2 (Nrf2). In addition, it lowered the levels of inflammatory cytokines and the nuclear levels of the nuclear factor kappa beta p65 (NF-kappa B p65). All these biochemical changes were associated with an increment in the phosphorylation of AMPK (p-AMPK) (activation) and reduced mRNA levels of SREBP1 and SREBP2. All observed effects afforded by Zingerone were abolished by CC. In conclusion, Zingerone prevents hepatic oxidative stress, inflammation, and apoptosis by activating AMPK.
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