Heptafluoroisopropylthiolation of benzyl halides

Heptafluoroisopropylthio group (-SCF(CF3)(2)) has bioactivities in insecticidal molecules, but the protocol for direct introduction of-SCF(CF3)(2) is under-explored. Described here is a protocol on heptafluoroisopropylthiolation of benzyl halides with a hexafluoropropylene (HFP)/CsF/S-8 system. The reaction enables the rapid construction of a range of (CF3)(2)CFS-containing compounds from readily available materials. This protocol may find application in the synthesis of (CF3)(2)CFS-containing biologically active molecules.

Automated summary

A protocol is described for the heptafluoroisopropylthiolation of benzyl halides using a HFP/CsF/S-8 system, enabling the rapid synthesis of (CF3)2CFS-containing compounds. This method shows potential for the synthesis of biologically active molecules.