期刊
JOURNAL OF FELINE MEDICINE AND SURGERY
卷 24, 期 3, 页码 257-265出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1098612X221079711
关键词
Disorder; sexual; development; intersex; ambiguity; anomalies
This article summarizes the various disorders of sexual development (DSD) in cats, including abnormalities of the reproductive tract and the changes in classification methods. The new classification is based on sex chromosome abnormalities, gonadal type, and documentation of internal and external genital components. The article draws on feline peer-reviewed literature and applies the classification to review the diseases.
Practical relevance: Any congenital or developmental abnormality of any part of the male or female reproductive tract is a 'disorder of sexual development' (DSD). The tricolored male cat phenotype, cryptorchidism, gonadal hypoplasia and incidental abnormalities such as cystic remnants or embryonic ducts are well-known feline DSDs. Clinical challenges: Full characterization of DSDs requires sex chromosome determination and identification of genes related to development of the gonads, internal tubular genitalia and external genitalia. Fortunately, affected cats are seen sporadically and the clinical effects are usually minimal. Classification: The classification nomenclature has changed. In place of intersex, hermaphrodite, pseudohermaphrodite and sex reversal, the newer standard classification, based on sex chromosomes, designates sex chromosome DSD when there is an abnormality in the sex chromosomes, and XX (female) and XY (male) DSDs where there is not. Identification of the gonadal type (testes, ovaries, ovotestes or gonadal dysgenesis) and documentation of the internal and external genital components completes the classification. Evidence base: The original basis of the DSD classification was a consensus reached in humans. It was quickly accepted in veterinary pathology, courtesy of its logic and ease of application, and it has subsequently begun to appear in peer-reviewed papers and clinical reviews. This article reviewing the various disorders in cats is based on application of the classification and draws on the feline peer-reviewed literature encompassing chromosome analysis and definition of reproductive abnormalities, syndromes and diseases.
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