期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 219, 期 6, 页码 -出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20220011
关键词
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资金
- Cold Spring Harbor Laboratory Northwell Health Affiliation
- Canadian Institutes of Health Research [PJT-159742, PJT-178306]
- Terry Fox Research Institute
- Tier II Canada Research Chair
- Medical Research Council [MR/R02149x/1]
- National Institutes of Health (NIH) [R01GM129633]
- NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR065959-01]
- Department of Defense [CDMRP LRP W81XWH-18-1-0674, CDMRP W81XWH-15-1-0717]
- NIH National Cancer Institute (NCI) [R01CA187392]
- Israel Science Foundation [1708/20, 405/18]
- Sasson and Luisa Naor Fund
- NIH National Institute of Allergy and Infectious Diseases [R01AI134987]
- Israel Cancer Research Fund
- Deutsche Forschungsgemeinschaft
- Rosetrees Trust
- European Commission [861878]
- Ministerio de Ciencia e Innovacion
- Pro-CNIC Foundation
- Intramural Research Program of the NIH
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [ZIAAR041199]
- European Research Council grant (ERC) [CoG-H2020-725492]
- Francis Crick Institute from Cancer Research UK [FC001112]
- UK Medical Research Council [FC001112]
- Wellcome Trust [FC001112]
- NIH/NCI Cancer Center Support Grant [P30 CA008748/NCI R01 CA056821]
- Swim Across America
- Ludwig Institute for Cancer Research
- Ludwig Center for Cancer Immunotherapy at Memorial Sloan Kettering
- Cancer Research Institute
- Parker Institute for Cancer Immunotherapy
- Swiss National Science Foundation [310030_179324]
- Fonds de la Recherche Scientifique [MISU F.6003.22]
- Institut Suisse de Recherche Experimentale sur le Cancer Foundation
- Ludwig Cancer Research
- NIH [P01CA240239, R01CA218579]
- Wellcome Trust Investigator Award [209422/Z/17/Z]
- Byondis BV
- Dutch Ministry of Health
- Dutch Cancer Society [10300, KWF10623, KWF10083, KWF13191]
- NIH National Health, Lung and Blood Institute [R35HL135765]
- NIH National Institute of General Medical Sciences [R35GM118337]
- Max Planck Society
- Oncode Institute
- Netherlands Organization for Scientific Research (NWO-VICI) [91819616]
- Department of Defense, Congressional Directed Medical Research Program [W81XWH2010753]
- Canadian Institutes of Health Research
- Swiss National Science Foundation (SNF) [310030_179324] Funding Source: Swiss National Science Foundation (SNF)
- U.S. Department of Defense (DOD) [W81XWH2010753] Funding Source: U.S. Department of Defense (DOD)
- Wellcome Trust [209422/Z/17/Z] Funding Source: Wellcome Trust
This article discusses the functional states and heterogeneity of neutrophils in cancer and provides a consensus statement on the controversies and solutions in neutrophil research. Further research is needed to understand the role of neutrophils in cancer and explore potential novel opportunities for cancer treatment.
There is a growing appreciation for the vastness of neutrophil functional states in cancer. Quail et al. provide a consensus statement on mechanisms governing neutrophil heterogeneity in the context of malignancy and discuss controversies and solutions in neutrophil research. Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.
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