期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 37, 期 1, 页码 1120-1195出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756366.2022.2061966
关键词
Hyaluronidase; tyrosinase plant-based inhibitors; structure-activity relationship; polyphenols
资金
- Nicolaus Copernicus University under the Excellence Initiative -Research University programme Emerging Fields (EF)/Sustainable development
- Polish-Dutch Platform of plant-based medicines
Plants have been used for thousands of years to treat various diseases, thanks to their rich source of natural compounds with diverse biological activities. This review focuses on the anti-tyrosinase and anti-hyaluronidase activities of phytochemicals, exploring their potential applications and future prospects.
Human has used plants to treat many civilisation diseases for thousands of years. Examples include reserpine (hypertension therapy), digoxin (myocardial diseases), vinblastine and vincristine (cancers), and opioids (palliative treatment). Plants are a rich source of natural metabolites with multiple biological activities, and the use of modern approaches and tools allowed finally for more effective bioprospecting. The new phytochemicals are hyaluronidase (Hyal) inhibitors, which could serve as anti-cancer drugs, male contraceptives, and an antidote against venoms. In turn, tyrosinase inhibitors can be used in cosmetics/pharmaceuticals as whitening agents and to treat skin pigmentation disorders. However, the activity of these inhibitors is stricte dependent on their structure and the presence of the chemical groups, e.g. carbonyl or hydroxyl. This review aims to provide comprehensive and in-depth evidence related to the anti-tyrosinase and anti-Hyal activity of phytochemicals as well as confirming their efficiency and future perspectives.
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