Gellan gum (GG)-based IPN microbeads for sustained drug release

The intent of current study was formulation and evaluation Al+3-ions induced ionically gelled cross-linked interpenetrated polymer network (IPN) based microbeads made of homopolymeric blends of carboxymethyl tamarind gum and gellan gum for prolonged sustained release of diclofenac sodium. Spherical diclofenac sodium loaded carboxymethyl tamarind gum-gellan gum IPN microbeads were accomplished by ionic gelation technique. These microbeads with diameters in the 601-700 mu m range demonstrated excellent drug entrapment (34.50 +/- 1.05 to 90.54 +/- 0.81% efficiency). Fourier transform-infrared, X-ray diffraction and differential scanning calorimetry experiments were used to characterize diclofenac sodium-loaded carboxymethyl tamarind gum-gellan gum IPN microbeads. Various microbeads exhibited prolonged sustained release of diclofenac sodium over 8 h duration and also found to follow the Korsmeyer-Peppas model (R-2 = 0.9937-0.9978). The in vivo pharmacodynamic results suggested the anti-inflammatory effect of diclofenac sodium-loaded carboxymethyl tamarind gum-gellan gum IPN microbeads in a sustained action manner.

Automated summary

This study developed diclofenac sodium-loaded carboxymethyl tamarind gum-gellan gum IPN microbeads using ionic gelation technique. The microbeads showed excellent drug entrapment and sustained release of diclofenac sodium over 8 hours, following the Korsmeyer-Peppas model. In vivo pharmacodynamic results demonstrated the sustained anti-inflammatory effect of these microbeads.