期刊
JOURNAL OF DERMATOLOGY
卷 49, 期 5, 页码 525-533出版社
WILEY
DOI: 10.1111/1346-8138.16329
关键词
CCL3; CXCL10; CXCL8; CXCL9; rosacea
类别
资金
- National Natural Science Foundation of China [81874251, 82003385]
This study examined the serum levels of various chemokines in rosacea patients and found that the concentrations of CCL3, CXCL8, CXCL9, and CXCL10 were significantly increased. The levels of these chemokines correlated with the severity of rosacea. The expression of their corresponding receptors was also elevated in the skin lesions of rosacea patients and mouse model. These findings may contribute to the clinical diagnosis and treatment of rosacea.
Rosacea is a common chronic inflammatory skin disease involving millions of patients worldwide. Previous studies have highlighted the upregulation of a variety of chemokines in the skin lesions of both rosacea patient and rosacea-like mouse model. However, the serum levels of these chemokines and their clinical significance have not been explored before. In this study, we aimed at examining the serum levels of a series of chemokines (including CCL2, CCL3, CCL20, CXCL1, CXCL8, CXCL9, CXCL10, and CXCL12) implicated in rosacea and their correlation with disease severity. Bio-Plex Pro Human Chemokine Assays were used to measure the serum levels of these chemokines. Investigator's Global Assessment (IGA) was applied for assessing the papules/pustules of rosacea patients, while persistent erythema was evaluated by the Clinician's Erythema Assessment (CEA). Our results revealed that the serum concentration of CCL3, CXCL8, CXCL9, and CXCL10 were markedly elevated in rosacea patients compared to healthy controls. Among them, the levels of CCL3, CXCL8, and CXCL9 were positively correlated with the IGA score, while serum CXCL9 and CXCL10 were positively related with the CEA score of rosacea patients. What's more, the expression of the corresponding receptors of CCL3 (Ccr1), CXCL8 (Cxcr1 and Cxcr2), CXCL9, and CXCL10 (Cxcr3) were all significantly increased in the skin lesions of rosacea-like mouse model with CXCR2 and CXCR3 highly expressed in rosacea patient skins. Our results indicated that CCL3, CXCL8, CXCL9, and CXCL10 might potentially serve as serum indicators for rosacea and could assist the severity evaluation of disease. Findings in this study would also potentially help to develop new targeted therapies for rosacea in future. (c) 2022 Japanese Dermatological Association
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