4.6 Article

Oral Microbiome of Crohn's Disease Patients With and Without Oral Manifestations

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Dentistry, Oral Surgery & Medicine

A double-edged sword: Role of butyrate in the oral cavity and the gut

Xiaoyuan Guan et al.

Summary: Butyrate, a metabolite of anaerobic bacteria, plays crucial roles in the gut and oral cavity, influencing various diseases such as periodontitis. Despite its diverse functions in different organs, the impact of butyrate on different diseases provides valuable insights for further research.

MOLECULAR ORAL MICROBIOLOGY (2021)

Review Pediatrics

The Oral Microbiome in Pediatric IBD: A Source of Pathobionts or Biomarkers?

Khalid Elmaghrawy et al.

Summary: The oral microbiome may play an important role in the development of gastrointestinal diseases, including Crohn's disease and ulcerative colitis. Bacteria and yeasts from the oral cavity may translocate to the gut, triggering inflammation, and dysbiosis of the oral microbiome could potentially serve as a biomarker for GI health.

FRONTIERS IN PEDIATRICS (2021)

Article Gastroenterology & Hepatology

Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn's disease

Shijia Hu et al.

Summary: This study characterized the gut and oral microbiome of Asian Crohn's disease (CD) patients using whole genome shotgun sequencing, revealing the enrichment of oral bacteria such as Streptococcus salivarius in the gut microbiome of CD patients. Additionally, distinct differences in gut microbial species abundance were observed between CD patients and healthy controls, with potential associations to disease activity. Ectopic gut colonization by oral bacteria was evidenced, especially during the active phase of CD, highlighting geographical/ethnic differences compared to subjects of European descent. Moreover, variations in microbial pathways provide potential targets for microbiome modification.

GUT PATHOGENS (2021)

Article Biochemical Research Methods

Multivariable association discovery in population-scale meta-omics studies

Himel Mallick et al.

Summary: The paper introduces a statistical model called MaAsLin 2 for multivariable associations in population-scale microbial community studies, which has been extensively validated. The authors highlight the importance and challenges of multivariable association analysis in microbiome research, and propose a new method to handle such complex data.

PLOS COMPUTATIONAL BIOLOGY (2021)

Article Gastroenterology & Hepatology

Site- and Taxa-Specific Disease-Associated Oral Microbial Structures Distinguish Inflammatory Bowel Diseases

Hari K. Somineni et al.

Summary: The study reveals significant dysbiosis in the oral microbiome of patients with inflammatory bowel disease (IBD), with different sites and bacterial groups affected to varying degrees. Salivary microbiota shows the best performance in distinguishing IBD patients from healthy controls, with some taxa consistently perturbed and site-dependent changes observed over time.

INFLAMMATORY BOWEL DISEASES (2021)

Article Biology

Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

Francesco Beghini et al.

Summary: Culture-independent analyses of microbial communities have advanced significantly in the past decade, particularly due to the emergence of Shotgun Metagenomics. bioBakery 3, a newly developed toolset, enhances the accuracy and scope of taxonomic, functional, and phylogenetic profiling in microbial community studies by providing an expanding set of reference sequences.
Review Microbiology

Systematic Review: The Gut Microbiome and Its Potential Clinical Application in Inflammatory Bowel Disease

Laila Aldars-Garcia et al.

Summary: IBD is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, and the gut microbiome plays a crucial role in its pathogenesis by showing reduced species richness, diversity, and temporal stability. Changes in the gut microbiome are pivotal in determining the onset of IBD, with certain microbial taxa identified as diagnostic biomarkers.

MICROORGANISMS (2021)

Article Gastroenterology & Hepatology

The role of oral bacteria in inflammatory bowel disease

Emily Read et al.

Summary: This perspective discusses the potential direct role of oral-associated bacteria in the pathogenesis of inflammatory bowel disease, suggesting that these bacteria may exacerbate inflammation in the intestine. Changes in the oral bacterial microbiota are associated with various inflammatory conditions, and it is proposed that oral disease-associated bacteria could translocate to the intestine and directly worsen the disease. The evidence supporting this hypothesis is critically evaluated in the context of other diseases where oral bacteria have been implicated.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Multidisciplinary Sciences

Pathway paradigms revealed from the genetics of inflammatory bowel disease

Daniel B. Graham et al.

NATURE (2020)

Article Dentistry, Oral Surgery & Medicine

Periodontitis and inflammatory bowel disease: a meta-analysis

Yang-yang She et al.

BMC ORAL HEALTH (2020)

Review Dentistry, Oral Surgery & Medicine

The role of the microbiota in periodontal disease

Mike A. Curtis et al.

PERIODONTOLOGY 2000 (2020)

Article Immunology

Dynamics of the Salivary Microbiome During Different Phases of Crohn's Disease

Tianyu Zhang et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Jason Lloyd-Price et al.

NATURE (2019)

Review Microbiology

Microbial genes and pathways in inflammatory bowel disease

Melanie Schirmer et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Article Gastroenterology & Hepatology

The microbiome reflects diagnosis and predicts disease severity in paediatric onset inflammatory bowel disease

Mikkel Malham et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2019)

Article Multidisciplinary Sciences

Remission in Crohn's disease is accompanied by alterations in the gut microbiota and mucins production

Daniela Oliveira Magro et al.

SCIENTIFIC REPORTS (2019)

Review Pharmacology & Pharmacy

Protective Mechanisms of Butyrate on Inflammatory Bowel Disease

Joao P. B. Silva et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

Article Gastroenterology & Hepatology

The microbiome of Crohn's disease aphthous ulcers

Claire L. O'Brien et al.

GUT PATHOGENS (2018)

Article Biochemical Research Methods

bioBakery: a meta'omic analysis environment

Lauren J. McIver et al.

BIOINFORMATICS (2018)

Article Nutrition & Dietetics

Nutritional Correlates of Human Oral Microbiome

Ikuko Kato et al.

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION (2017)

Article Gastroenterology & Hepatology

A microbial signature for Crohn's disease

Victoria Pascal et al.

Review Medicine, General & Internal

Crohn's disease

Joana Torres et al.

LANCET (2017)

Review Gastroenterology & Hepatology

Extraintestinal Manifestations of Inflammatory Bowel Disease

Stephan R. Vavricka et al.

INFLAMMATORY BOWEL DISEASES (2015)

Review Immunology

Diagnosis and classification of Crohn's disease

Martin W. Laass et al.

AUTOIMMUNITY REVIEWS (2014)

Article Microbiology

The Treatment-Naive Microbiome in New-Onset Crohn's Disease

Dirk Gevers et al.

CELL HOST & MICROBE (2014)

Review Gastroenterology & Hepatology

Oral manifestation in inflammatory bowel disease: A review

Kamran B. Lankarani et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

Article Gastroenterology & Hepatology

Alterations in diversity of the oral microbiome in pediatric inflammatory bowel disease

Michael J. Docktor et al.

INFLAMMATORY BOWEL DISEASES (2012)

Article Medicine, General & Internal

Crohn's disease

Daniel C. Baumgart et al.

LANCET (2012)

Article Gastroenterology & Hepatology

Disease Phenotype and Genotype Are Associated with Shifts in Intestinal-associated Microbiota in Inflammatory Bowel Diseases

Daniel N. Frank et al.

INFLAMMATORY BOWEL DISEASES (2011)

Review Gastroenterology & Hepatology

Management of Crohn's Disease in Adults

Gary R. Lichtenstein et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2009)

Article Gastroenterology & Hepatology

Oral butyrate for mildly to moderately active Crohn's disease

A Di Sabatino et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2005)

Article Gastroenterology & Hepatology

A prospective study of the oral manifestations of Crohn's disease

S Harty et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2005)